Cervical flexion: Its contribution to normal and abnormal cardiac morphogenesis

Kenjiro Kosaki, Arturo Mendoza, Kenneth Lyons Jones

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Although His in 1881 and Patten in 1922 suggested that cervical flexion could play an important role in normal cardiac morphogenesis, until recently this hypothesis has been largely neglected. The purpose of this report is to present data indicating that prevention of cervical flexion leads to double outlet right ventricle (DORV), which is unrelated to any affect on neural crest cell migration. At stage 11-12, suture material was inserted into the neural tube to prevent cervical flexion. Six out of 22 experimental embryos survived until stage 38 and 5 out of 6 had DORV. Neither abnormalities of the aortico-pulmonary septum nor interruption of the aortic arch were observed at dissection. Hemodynamic studies performed at stage 18 revealed distinctive characteristics that are inconsistent with hemodynamic studies previously reported following neural crest ablation. With respect to immunohistochemical studies using neural crest associated antigen HNK-1 antibody, normal migration of neural crest cells was noted in the outflow tract in the experimental embryos at stage 22. These hemodynamic and immunohistochemical studies suggest that insertion of suture material into the neural tube at stage 11-12 does not jeopardize neural crest migration. We propose that reduction in cervical flexion increases the distance between the future aorta and the left ventricle, which prevents the transition of intracardiac flow pattern from a serial circulation to a parallel one, leaving persistence of a 'double outlet' from the right ventricle.

Original languageEnglish
Pages (from-to)135-144
Number of pages10
JournalTeratology
Volume54
Issue number3
DOIs
Publication statusPublished - 1996 Sep
Externally publishedYes

Fingerprint

Neural Crest
Hemodynamics
Morphogenesis
Double Outlet Right Ventricle
CD57 Antigens
Neural Tube
Dissection
Sutures
Arches
Ablation
Flow patterns
Embryonic Structures
Thoracic Aorta
Antibodies
Heart Ventricles
Cell Movement
Aorta
Lung

ASJC Scopus subject areas

  • Developmental Biology
  • Embryology
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Cervical flexion : Its contribution to normal and abnormal cardiac morphogenesis. / Kosaki, Kenjiro; Mendoza, Arturo; Jones, Kenneth Lyons.

In: Teratology, Vol. 54, No. 3, 09.1996, p. 135-144.

Research output: Contribution to journalArticle

Kosaki, Kenjiro ; Mendoza, Arturo ; Jones, Kenneth Lyons. / Cervical flexion : Its contribution to normal and abnormal cardiac morphogenesis. In: Teratology. 1996 ; Vol. 54, No. 3. pp. 135-144.
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