Change in visual acuity and associated risk factors after trabeculectomy with adjunctive mitomycin C

the Collaborative Bleb-Related Infection Incidence and Treatment Study Group

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Purpose: To report the 5-year incidence of visual impairment after mitomycin C-augmented trabeculectomy (MMC trabeculectomy) and the risk factors for visual impairment. Methods: This is a multicentre prospective observational cohort study. Among glaucoma patients registered in the Collaborative Bleb-related Infection Incidence and Treatment Study performed in Japan, the patients with eyes meeting the following qualifications were included: eyes with primary open-angle glaucoma; eyes with primary angle-closure glaucoma; eyes with exfoliative glaucoma; eyes with ≥3/60 in blindness analysis; and eyes with ≥20/60 in low-vision analysis and visual acuity loss analysis. The patients were followed at 6-month intervals for 5 years. The entry data and follow-up data were analysed to determine the incidence of blindness (<3/60), low vision (≥3/60 and <20/60) and visual acuity loss (≥0.2 logMAR) during the follow-up period. Risk factors for visual impairment were also analysed. Results: A total of 694 eyes of 694 or 559 eyes of 559 glaucoma patients were subjected to the blindness analysis or the low-vision and visual acuity loss analysis, respectively. Visual acuity significantly deteriorated (p < 0.0001): 12.2% (95%CI: 9.8–14.7%) of the patients became blind; 12.1% (95%CI: 9.4–14.9%) were judged to have low vision at the final examination; 28.3% (95%CI: 24.5–32.0%) were judged to have visual acuity loss. Glaucoma subtypes, poor preoperative visual function and postoperative complications are the main risk factors for visual impairment. Conclusions: Visual acuity was significantly reduced after MMC trabeculectomy in 5 years, and we identified several risk factors associated with this complication.

Original languageEnglish
Pages (from-to)e561-e570
JournalActa Ophthalmologica
Volume94
Issue number7
DOIs
Publication statusPublished - 2016 Nov 1

Fingerprint

Trabeculectomy
Mitomycin
Visual Acuity
Low Vision
Vision Disorders
Glaucoma
Blindness
Cohort Studies
Angle Closure Glaucoma
Incidence
Blister
Observational Studies
Japan
Infection

Keywords

  • blindness
  • glaucoma
  • incidence
  • low vision
  • trabeculectomy
  • visual acuity

ASJC Scopus subject areas

  • Ophthalmology

Cite this

the Collaborative Bleb-Related Infection Incidence and Treatment Study Group (2016). Change in visual acuity and associated risk factors after trabeculectomy with adjunctive mitomycin C. Acta Ophthalmologica, 94(7), e561-e570. https://doi.org/10.1111/aos.13058

Change in visual acuity and associated risk factors after trabeculectomy with adjunctive mitomycin C. / the Collaborative Bleb-Related Infection Incidence and Treatment Study Group.

In: Acta Ophthalmologica, Vol. 94, No. 7, 01.11.2016, p. e561-e570.

Research output: Contribution to journalArticle

the Collaborative Bleb-Related Infection Incidence and Treatment Study Group 2016, 'Change in visual acuity and associated risk factors after trabeculectomy with adjunctive mitomycin C', Acta Ophthalmologica, vol. 94, no. 7, pp. e561-e570. https://doi.org/10.1111/aos.13058
the Collaborative Bleb-Related Infection Incidence and Treatment Study Group. Change in visual acuity and associated risk factors after trabeculectomy with adjunctive mitomycin C. Acta Ophthalmologica. 2016 Nov 1;94(7):e561-e570. https://doi.org/10.1111/aos.13058
the Collaborative Bleb-Related Infection Incidence and Treatment Study Group. / Change in visual acuity and associated risk factors after trabeculectomy with adjunctive mitomycin C. In: Acta Ophthalmologica. 2016 ; Vol. 94, No. 7. pp. e561-e570.
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abstract = "Purpose: To report the 5-year incidence of visual impairment after mitomycin C-augmented trabeculectomy (MMC trabeculectomy) and the risk factors for visual impairment. Methods: This is a multicentre prospective observational cohort study. Among glaucoma patients registered in the Collaborative Bleb-related Infection Incidence and Treatment Study performed in Japan, the patients with eyes meeting the following qualifications were included: eyes with primary open-angle glaucoma; eyes with primary angle-closure glaucoma; eyes with exfoliative glaucoma; eyes with ≥3/60 in blindness analysis; and eyes with ≥20/60 in low-vision analysis and visual acuity loss analysis. The patients were followed at 6-month intervals for 5 years. The entry data and follow-up data were analysed to determine the incidence of blindness (<3/60), low vision (≥3/60 and <20/60) and visual acuity loss (≥0.2 logMAR) during the follow-up period. Risk factors for visual impairment were also analysed. Results: A total of 694 eyes of 694 or 559 eyes of 559 glaucoma patients were subjected to the blindness analysis or the low-vision and visual acuity loss analysis, respectively. Visual acuity significantly deteriorated (p < 0.0001): 12.2{\%} (95{\%}CI: 9.8–14.7{\%}) of the patients became blind; 12.1{\%} (95{\%}CI: 9.4–14.9{\%}) were judged to have low vision at the final examination; 28.3{\%} (95{\%}CI: 24.5–32.0{\%}) were judged to have visual acuity loss. Glaucoma subtypes, poor preoperative visual function and postoperative complications are the main risk factors for visual impairment. Conclusions: Visual acuity was significantly reduced after MMC trabeculectomy in 5 years, and we identified several risk factors associated with this complication.",
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T1 - Change in visual acuity and associated risk factors after trabeculectomy with adjunctive mitomycin C

AU - the Collaborative Bleb-Related Infection Incidence and Treatment Study Group

AU - Kashiwagi, Kenji

AU - Kogure, Satoshi

AU - Mabuchi, Fumihiko

AU - Chiba, Tatsuya

AU - Yamamoto, Tetsuya

AU - Kuwayama, Yasuaki

AU - Araie, Makoto

AU - Aihara, Makoto

AU - Abe, Haruki

AU - Iwase, Aiko

AU - Uji, Yukitaka

AU - Katsushima, Harumi

AU - Kitazawa, Yoshiaki

AU - Sawaguchi, Shoichi

AU - Shimizu, Hiroshi

AU - Shirato, Shiroaki

AU - Sugiyama, Kazuhisa

AU - Suzuki, Yasuyuki

AU - Tanihara, Hidenobu

AU - Tawara, Akihiko

AU - Tomita, Goji

AU - Tomidokoro, Atsuo

AU - Negi, Akira

AU - Fukuchi, Takeo

AU - Matsumoto, Chota

AU - Mishima, Hiromu K.

AU - Yoshikawa, Keiji

AU - Yoshitomi, Takeshi

AU - Inoue, Yoshitsugu

AU - Aoyama, Yumiko

AU - Kawase, Kazuhide

AU - Ban, Takahiro

AU - Sawada, Akira

AU - Mochizuki, Kiyofumi

AU - Futa, Ryusuke

AU - Nakamoto, Kenji

AU - Sugiyama, Tetsuya

AU - Kojima, Shota

AU - Hirotsuji, Norihiko

AU - Kano, Kiyoshi

AU - Ohura, Atsushi

AU - Kawai, Eriko

AU - Nakata, Atsuko

AU - Kuwamura, Rika

AU - Okuno, Kensuke

AU - Yawata, Kenji

AU - Matsumoto, Shun

AU - Abe, Haruki

AU - Fukuchi, Takeo

AU - Yuki, Kenya

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Purpose: To report the 5-year incidence of visual impairment after mitomycin C-augmented trabeculectomy (MMC trabeculectomy) and the risk factors for visual impairment. Methods: This is a multicentre prospective observational cohort study. Among glaucoma patients registered in the Collaborative Bleb-related Infection Incidence and Treatment Study performed in Japan, the patients with eyes meeting the following qualifications were included: eyes with primary open-angle glaucoma; eyes with primary angle-closure glaucoma; eyes with exfoliative glaucoma; eyes with ≥3/60 in blindness analysis; and eyes with ≥20/60 in low-vision analysis and visual acuity loss analysis. The patients were followed at 6-month intervals for 5 years. The entry data and follow-up data were analysed to determine the incidence of blindness (<3/60), low vision (≥3/60 and <20/60) and visual acuity loss (≥0.2 logMAR) during the follow-up period. Risk factors for visual impairment were also analysed. Results: A total of 694 eyes of 694 or 559 eyes of 559 glaucoma patients were subjected to the blindness analysis or the low-vision and visual acuity loss analysis, respectively. Visual acuity significantly deteriorated (p < 0.0001): 12.2% (95%CI: 9.8–14.7%) of the patients became blind; 12.1% (95%CI: 9.4–14.9%) were judged to have low vision at the final examination; 28.3% (95%CI: 24.5–32.0%) were judged to have visual acuity loss. Glaucoma subtypes, poor preoperative visual function and postoperative complications are the main risk factors for visual impairment. Conclusions: Visual acuity was significantly reduced after MMC trabeculectomy in 5 years, and we identified several risk factors associated with this complication.

AB - Purpose: To report the 5-year incidence of visual impairment after mitomycin C-augmented trabeculectomy (MMC trabeculectomy) and the risk factors for visual impairment. Methods: This is a multicentre prospective observational cohort study. Among glaucoma patients registered in the Collaborative Bleb-related Infection Incidence and Treatment Study performed in Japan, the patients with eyes meeting the following qualifications were included: eyes with primary open-angle glaucoma; eyes with primary angle-closure glaucoma; eyes with exfoliative glaucoma; eyes with ≥3/60 in blindness analysis; and eyes with ≥20/60 in low-vision analysis and visual acuity loss analysis. The patients were followed at 6-month intervals for 5 years. The entry data and follow-up data were analysed to determine the incidence of blindness (<3/60), low vision (≥3/60 and <20/60) and visual acuity loss (≥0.2 logMAR) during the follow-up period. Risk factors for visual impairment were also analysed. Results: A total of 694 eyes of 694 or 559 eyes of 559 glaucoma patients were subjected to the blindness analysis or the low-vision and visual acuity loss analysis, respectively. Visual acuity significantly deteriorated (p < 0.0001): 12.2% (95%CI: 9.8–14.7%) of the patients became blind; 12.1% (95%CI: 9.4–14.9%) were judged to have low vision at the final examination; 28.3% (95%CI: 24.5–32.0%) were judged to have visual acuity loss. Glaucoma subtypes, poor preoperative visual function and postoperative complications are the main risk factors for visual impairment. Conclusions: Visual acuity was significantly reduced after MMC trabeculectomy in 5 years, and we identified several risk factors associated with this complication.

KW - blindness

KW - glaucoma

KW - incidence

KW - low vision

KW - trabeculectomy

KW - visual acuity

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