Change of the blood concentration of tacrolimus after the switch from fluconazole to voriconazole in patients receiving allogeneic hematopoietic stem cell transplantation

Hitoshi Kawazoe; Yoshiharu Takiguchi; Hiroaki Tanaka; Noriyasu Fukuoka; Hiroaki Ohnishi; Toshihiko Ishida; Hitoshi Houchi

doi:10.1248/bpb.29.2528

Change of the blood concentration of tacrolimus after the switch from fluconazole to voriconazole in patients receiving allogeneic hematopoietic stem cell transplantation

Hitoshi Kawazoe, Yoshiharu Takiguchi, Hiroaki Tanaka, Noriyasu Fukuoka, Hiroaki Ohnishi, Toshihiko Ishida, Hitoshi Houchi

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

The purpose of this study was to assess the impact by switching co-administered triazole antifungal agent from fluconazole (FCZ) to voriconazole (VCZ) on the blood concentration of tacrolimus (FK506) in patients receiving allogeneic hematopoietic stem cell transplantation. We performed a retrospective study presented as case reports. The blood concentration of FK506 was increased after the switch from FCZ to VCZ, resulting in increase of the concentration/dose (C/D) ratio of FK506. Thus, the mean C/D ratios of FK506 with oral administration was surprisingly increased over 4.5-fold after the switch. Therefore, it was necessary to reduce the FK506 dose when co-administered FCZ is switched to VCZ. We should be careful when interpreting the results of these case reports; however, in some patients, it is recommended that the dose of FK506 be reduced to one-fifth after the switch.

Original language	English
Pages (from-to)	2528-2531
Number of pages	4
Journal	Biological and Pharmaceutical Bulletin
Volume	29
Issue number	12
DOIs	https://doi.org/10.1248/bpb.29.2528
Publication status	Published - 2006 Dec
Externally published	Yes

Keywords

Concentration
Interaction
Tacrolimus
Transplantation
Voriconazole

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

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10.1248/bpb.29.2528

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Change of the blood concentration of tacrolimus after the switch from fluconazole to voriconazole in patients receiving allogeneic hematopoietic stem cell transplantation. / Kawazoe, Hitoshi; Takiguchi, Yoshiharu; Tanaka, Hiroaki et al.
In: Biological and Pharmaceutical Bulletin, Vol. 29, No. 12, 12.2006, p. 2528-2531.

Research output: Contribution to journal › Article › peer-review

Kawazoe, H, Takiguchi, Y, Tanaka, H, Fukuoka, N, Ohnishi, H, Ishida, T & Houchi, H 2006, 'Change of the blood concentration of tacrolimus after the switch from fluconazole to voriconazole in patients receiving allogeneic hematopoietic stem cell transplantation', Biological and Pharmaceutical Bulletin, vol. 29, no. 12, pp. 2528-2531. https://doi.org/10.1248/bpb.29.2528

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abstract = "The purpose of this study was to assess the impact by switching co-administered triazole antifungal agent from fluconazole (FCZ) to voriconazole (VCZ) on the blood concentration of tacrolimus (FK506) in patients receiving allogeneic hematopoietic stem cell transplantation. We performed a retrospective study presented as case reports. The blood concentration of FK506 was increased after the switch from FCZ to VCZ, resulting in increase of the concentration/dose (C/D) ratio of FK506. Thus, the mean C/D ratios of FK506 with oral administration was surprisingly increased over 4.5-fold after the switch. Therefore, it was necessary to reduce the FK506 dose when co-administered FCZ is switched to VCZ. We should be careful when interpreting the results of these case reports; however, in some patients, it is recommended that the dose of FK506 be reduced to one-fifth after the switch.",

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AU - Tanaka, Hiroaki

AU - Fukuoka, Noriyasu

AU - Ohnishi, Hiroaki

AU - Ishida, Toshihiko

AU - Houchi, Hitoshi

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Change of the blood concentration of tacrolimus after the switch from fluconazole to voriconazole in patients receiving allogeneic hematopoietic stem cell transplantation

Abstract

Keywords

ASJC Scopus subject areas

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