Change of the blood concentration of tacrolimus after the switch from fluconazole to voriconazole in patients receiving allogeneic hematopoietic stem cell transplantation

Hitoshi Kawazoe, Yoshiharu Takiguchi, Hiroaki Tanaka, Noriyasu Fukuoka, Hiroaki Ohnishi, Toshihiko Ishida, Hitoshi Houchi

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The purpose of this study was to assess the impact by switching co-administered triazole antifungal agent from fluconazole (FCZ) to voriconazole (VCZ) on the blood concentration of tacrolimus (FK506) in patients receiving allogeneic hematopoietic stem cell transplantation. We performed a retrospective study presented as case reports. The blood concentration of FK506 was increased after the switch from FCZ to VCZ, resulting in increase of the concentration/dose (C/D) ratio of FK506. Thus, the mean C/D ratios of FK506 with oral administration was surprisingly increased over 4.5-fold after the switch. Therefore, it was necessary to reduce the FK506 dose when co-administered FCZ is switched to VCZ. We should be careful when interpreting the results of these case reports; however, in some patients, it is recommended that the dose of FK506 be reduced to one-fifth after the switch.

Original languageEnglish
Pages (from-to)2528-2531
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Volume29
Issue number12
DOIs
Publication statusPublished - 2006 Dec 1
Externally publishedYes

Keywords

  • Concentration
  • Interaction
  • Tacrolimus
  • Transplantation
  • Voriconazole

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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