Changes in high mannose-type glycoproteins of peripheral blood mononuclear cells in cirrhosis patients

Shingo Miyaguchi, Toshio Morizane, Tatehiro Kagawa, Ferdinand Morales Guevara, Hidetsugu Saito, Masaharu Tsuchiya

Research output: Contribution to journalArticle

Abstract

Glycoproteins of peripheral blood mononuclear cells (PBMC) in patients with liver cirrhosis (LC) have not yet been studied. In the present study, we investigated high mannose-type glycoproteins of PBMC from patients with LC. We showed that [2-3H]mannose uptake by PBMC and binding of glycoproteins from PBMC to concanavalin A (Con A)-Sepharose were significantly lower in patients with LC than in healthy subjects. These results indicate that high mannose-type glycoproteins of PBMC are decreased in patients with LC. High mannose-type glycoproteins play an important role in the formation of functional high-affinity interleukin-2 (IL-2) receptors. Thus, the decrease of high mannose-type glycoproteins may be one of the factors affecting the function of T or natural killer (NK) cells, which require IL-2 receptors to exert various immunological functions, in patients with LC.

Original languageEnglish
Pages (from-to)41-47
Number of pages7
JournalInternational Hepatology Communications
Volume3
Issue number1
DOIs
Publication statusPublished - 1995

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Keywords

  • High mannose-type glycoprotein
  • Liver cirrhosis
  • Peripheral mononuclear cells

ASJC Scopus subject areas

  • Hepatology

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