Changes in intracortical inhibition and clinical symptoms after STN-DBS in Parkinson's disease

Masahito Kobayashi, Takayuki Oohira, Ban Mihara, Takamitsu Fujimaki

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives: To examine effects of subthalamic nucleus deep brain stimulation (STN-DBS) on intracortical inhibition in Parkinson's disease (PD) and the correlation between intracortical inhibition and clinical symptoms after alteration of STN-DBS status. Methods: Nine PD patients treated by STN-DBS were compared with eight age-matched controls. Antiparkinsonian medication was withdrawn 12 h before the study. Short-interval intracortical inhibition (SICI) with a 3-ms interval and silent period (SP) were examined using transcranial magnetic stimulation. SP duration, SICI and motor symptoms (rigidity and tremor) were evaluated with STN-DBS ON, and over 120 min during STN-DBS OFF. Results: Even during STN-DBS, PD patients showed a shortened SP and reduced SICI relative to normal controls. SICI decreased further throughout STN-DBS OFF, resulting in facilitation rather than inhibition; SP shortened only after 120 min STN-DBS OFF. Both rigidity and tremor worsened throughout STN-DBS OFF, with a time course similar to SICI. Conclusion: Even during STN-DBS, both SICI and SP in PD patients remain impaired without medication. Changes in SICI, but not SP, show a time course similar to those of motor symptoms. Significance: The dissimilarity of SICI and SP changes suggests differences in mediation of inhibitory mechanisms and/or superimposition of exaggerated intracortical facilitation on SICI.

Original languageEnglish
Pages (from-to)2031-2037
Number of pages7
JournalClinical Neurophysiology
Volume127
Issue number4
DOIs
Publication statusPublished - 2016 Apr 1

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Subthalamic Nucleus
Deep Brain Stimulation
Parkinson Disease
Tremor
Antiparkinson Agents
Transcranial Magnetic Stimulation

Keywords

  • Intracortical inhibition
  • Parkinson's disease
  • Subthalamic nucleus deep brain stimulation

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)
  • Sensory Systems

Cite this

Changes in intracortical inhibition and clinical symptoms after STN-DBS in Parkinson's disease. / Kobayashi, Masahito; Oohira, Takayuki; Mihara, Ban; Fujimaki, Takamitsu.

In: Clinical Neurophysiology, Vol. 127, No. 4, 01.04.2016, p. 2031-2037.

Research output: Contribution to journalArticle

Kobayashi, Masahito ; Oohira, Takayuki ; Mihara, Ban ; Fujimaki, Takamitsu. / Changes in intracortical inhibition and clinical symptoms after STN-DBS in Parkinson's disease. In: Clinical Neurophysiology. 2016 ; Vol. 127, No. 4. pp. 2031-2037.
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