Changes in metabolic parameters following a switch to aripiprazole in Japanese patients with schizophrenia

One-year follow-up study

Hiroyoshi Takeuchi, Hiroyuki Uchida, Takefumi Suzuki, Koichiro Watanabe, Haruo Kashima

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The purpose of the present study was to evaluate changes in metabolic parameters after switching to aripiprazole in Japanese population. In this 1-year observation study, following a switch to aripiprazole, 32 patients with schizophrenia were observed and assessment was done of bodyweight, total cholesterol, triglyceride, serum prolactin level, and corrected QT (QTc) interval. Significant reductions were observed in these parameters other than QTc interval. Given known detrimental metabolic and hormonal effects of some atypical antipsychotics, a switch to aripiprazole may warrant serious consideration also in Asian patients who suffer those side-effects.

Original languageEnglish
Pages (from-to)104-106
Number of pages3
JournalPsychiatry and Clinical Neurosciences
Volume64
Issue number1
DOIs
Publication statusPublished - 2010 Feb

Fingerprint

Schizophrenia
Prolactin
Antipsychotic Agents
Triglycerides
Cholesterol
Observation
Serum
Population
Aripiprazole

Keywords

  • Antipsychotics
  • Aripiprazole
  • Metabolic
  • Side-effect

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Psychiatry and Mental health
  • Neuroscience(all)

Cite this

Changes in metabolic parameters following a switch to aripiprazole in Japanese patients with schizophrenia : One-year follow-up study. / Takeuchi, Hiroyoshi; Uchida, Hiroyuki; Suzuki, Takefumi; Watanabe, Koichiro; Kashima, Haruo.

In: Psychiatry and Clinical Neurosciences, Vol. 64, No. 1, 02.2010, p. 104-106.

Research output: Contribution to journalArticle

@article{5ca053c99cc348e296af41382a7a0b42,
title = "Changes in metabolic parameters following a switch to aripiprazole in Japanese patients with schizophrenia: One-year follow-up study",
abstract = "The purpose of the present study was to evaluate changes in metabolic parameters after switching to aripiprazole in Japanese population. In this 1-year observation study, following a switch to aripiprazole, 32 patients with schizophrenia were observed and assessment was done of bodyweight, total cholesterol, triglyceride, serum prolactin level, and corrected QT (QTc) interval. Significant reductions were observed in these parameters other than QTc interval. Given known detrimental metabolic and hormonal effects of some atypical antipsychotics, a switch to aripiprazole may warrant serious consideration also in Asian patients who suffer those side-effects.",
keywords = "Antipsychotics, Aripiprazole, Metabolic, Side-effect",
author = "Hiroyoshi Takeuchi and Hiroyuki Uchida and Takefumi Suzuki and Koichiro Watanabe and Haruo Kashima",
year = "2010",
month = "2",
doi = "10.1111/j.1440-1819.2009.02036.x",
language = "English",
volume = "64",
pages = "104--106",
journal = "Psychiatry and Clinical Neurosciences",
issn = "1323-1316",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Changes in metabolic parameters following a switch to aripiprazole in Japanese patients with schizophrenia

T2 - One-year follow-up study

AU - Takeuchi, Hiroyoshi

AU - Uchida, Hiroyuki

AU - Suzuki, Takefumi

AU - Watanabe, Koichiro

AU - Kashima, Haruo

PY - 2010/2

Y1 - 2010/2

N2 - The purpose of the present study was to evaluate changes in metabolic parameters after switching to aripiprazole in Japanese population. In this 1-year observation study, following a switch to aripiprazole, 32 patients with schizophrenia were observed and assessment was done of bodyweight, total cholesterol, triglyceride, serum prolactin level, and corrected QT (QTc) interval. Significant reductions were observed in these parameters other than QTc interval. Given known detrimental metabolic and hormonal effects of some atypical antipsychotics, a switch to aripiprazole may warrant serious consideration also in Asian patients who suffer those side-effects.

AB - The purpose of the present study was to evaluate changes in metabolic parameters after switching to aripiprazole in Japanese population. In this 1-year observation study, following a switch to aripiprazole, 32 patients with schizophrenia were observed and assessment was done of bodyweight, total cholesterol, triglyceride, serum prolactin level, and corrected QT (QTc) interval. Significant reductions were observed in these parameters other than QTc interval. Given known detrimental metabolic and hormonal effects of some atypical antipsychotics, a switch to aripiprazole may warrant serious consideration also in Asian patients who suffer those side-effects.

KW - Antipsychotics

KW - Aripiprazole

KW - Metabolic

KW - Side-effect

UR - http://www.scopus.com/inward/record.url?scp=75649110751&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=75649110751&partnerID=8YFLogxK

U2 - 10.1111/j.1440-1819.2009.02036.x

DO - 10.1111/j.1440-1819.2009.02036.x

M3 - Article

VL - 64

SP - 104

EP - 106

JO - Psychiatry and Clinical Neurosciences

JF - Psychiatry and Clinical Neurosciences

SN - 1323-1316

IS - 1

ER -