Changes in plasma endothelin in patients undergoing cardiac valve replacement under high dose fentanyl anesthesia

Y. Takino, M. Kondo, T. Kaneda, Y. Okamoto, Hiroshi Morisaki, M. Sato

Research output: Contribution to journalArticle

Abstract

We measured plasma endothelin (ET) in 11 patients undergoing cardiac valve replacement under high dose fentanyl (116.6 ± 15.4 μg · kg-1, mean ± SD) anesthesia. Arterial blood samples were obtained: 1) before induction of anesthesia (control), 2) just before the start of cardiopulmonary bypass (CPB), and 3) just before the end of CPB. Endothelin levels were analyzed by radioimmunoassay based on double antibody method using Silica ODS suspension. ET concentrations in period 1, 2, and 3 were 3.0 ± 1.1, 4.2 ± 1.7 and 4.5 ± 1.8 pg · ml-1 (mean ± SD), respectively. There were no significant differences among these three values (P < 0.05). The results suggest that under high dose fentanyl anesthesia, surgical stress including that of CPB might not affect ET concentration in plasma.

Original languageEnglish
Pages (from-to)1384-1386
Number of pages3
JournalJapanese Journal of Anesthesiology
Volume40
Issue number9
Publication statusPublished - 1991
Externally publishedYes

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Endothelins
Heart Valves
Fentanyl
Anesthesia
Cardiopulmonary Bypass
Silicon Dioxide
Radioimmunoassay
Suspensions
Antibodies

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Changes in plasma endothelin in patients undergoing cardiac valve replacement under high dose fentanyl anesthesia. / Takino, Y.; Kondo, M.; Kaneda, T.; Okamoto, Y.; Morisaki, Hiroshi; Sato, M.

In: Japanese Journal of Anesthesiology, Vol. 40, No. 9, 1991, p. 1384-1386.

Research output: Contribution to journalArticle

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AU - Kondo, M.

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AU - Sato, M.

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