Changes in plasma endothelin in patients undergoing cardiac valve replacement under high dose fentanyl anesthesia

Y. Takino, M. Kondo, T. Kaneda, Y. Okamoto, H. Morisaki, M. Sato

Research output: Contribution to journalArticle

Abstract

We measured plasma endothelin (ET) in 11 patients undergoing cardiac valve replacement under high dose fentanyl (116.6 ± 15.4 μg · kg-1, mean ± SD) anesthesia. Arterial blood samples were obtained: 1) before induction of anesthesia (control), 2) just before the start of cardiopulmonary bypass (CPB), and 3) just before the end of CPB. Endothelin levels were analyzed by radioimmunoassay based on double antibody method using Silica ODS suspension. ET concentrations in period 1, 2, and 3 were 3.0 ± 1.1, 4.2 ± 1.7 and 4.5 ± 1.8 pg · ml-1 (mean ± SD), respectively. There were no significant differences among these three values (P < 0.05). The results suggest that under high dose fentanyl anesthesia, surgical stress including that of CPB might not affect ET concentration in plasma.

Original languageEnglish
Pages (from-to)1384-1386
Number of pages3
JournalJapanese Journal of Anesthesiology
Volume40
Issue number9
Publication statusPublished - 1991 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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