Changes in the first line Helicobacter pylori eradication rates using the triple therapy-a multicenter study in the Tokyo metropolitan area (Tokyo Helicobacter pylori study group)

Takashi Kawai, Shin'ichi Takahashi, Hidekazu Suzuki, Hitoshi Sasaki, Akihito Nagahara, Daisuke Asaoka, Takeshi Matsuhisa, Tatsuhiro Masaoaka, Toshihiro Nishizawa, Masayuki Suzuki, Masayoshi Ito, Naoto Kurihara, Fumio Omata, Shigeaki Mizuno, Akira Torii, Kohei Kawakami, Toshifumi Ohkusa, Kengo Tokunaga, Tetsuya Mine, Nobuhiro Sakaki

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Background and Aim: Helicobacter pylori (H.pylori) infection is a strong risk factor for the development of gastric cancer. In 2013, the Japanese government approved H.pylori eradication therapy in patients with chronic gastritis as well as peptic ulcer. However, the continuing decline in eradication rates for first-line H.pylori eradication therapies is an urgent problem. In this study, we investigated changes in the first-line eradication rate from 2001 to 2010. Methods: Eradication rates for 7-day triple therapy [proton pump inhibitor (rabeprazole 20mg, lansoprazole 60mg, or omeprazole 40mg)+amoxicillin 1500mg+clarithromycin (CAM) 400 or 800mg, daily] were collated from 14 hospitals in the Tokyo metropolitan area. The urea breath test was used for the evaluation of eradication. The cut-off value was less than 2.5%. Results: The yearly eradication rates (intention to treat/per protocol) were 78.5/79.5% (2001, n=242), 71.2%/72.9% (2002, n=208), 67.8%/70.5% (2003, n=183), 75.6%/84.6% (2004, n=131), 56.4%/70.5% (2005, n=114), 70.5%/75.8% (2006, n=271), 67.4%/82.0% (2007,n=135), 64.0%/76.3% (2008, n=261), 60.5%/74.3% (2009, n=329), and 66.5%/78.8% (2010, n=370), respectively. Examination of eradication rates according to CAM dosage revealed an eradication rate of 65.6% (383/584) for CAM 400mg daily, and 68.5% (1124/1642) for CAM 800mg daily, with no significant difference seen between dosages. Conclusion: In recent years, eradication rates for first-line triple therapy have obviously decreased, but no noticeable decrease has occurred after 2001.

Original languageEnglish
Pages (from-to)29-32
Number of pages4
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume29
Issue numberS4
DOIs
Publication statusPublished - 2014 Dec 1

Keywords

  • Clarithromycin
  • Eradication rate
  • Helicobacter pylori
  • Proton pump inhibitor
  • Triple therapy

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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    Kawai, T., Takahashi, S., Suzuki, H., Sasaki, H., Nagahara, A., Asaoka, D., Matsuhisa, T., Masaoaka, T., Nishizawa, T., Suzuki, M., Ito, M., Kurihara, N., Omata, F., Mizuno, S., Torii, A., Kawakami, K., Ohkusa, T., Tokunaga, K., Mine, T., & Sakaki, N. (2014). Changes in the first line Helicobacter pylori eradication rates using the triple therapy-a multicenter study in the Tokyo metropolitan area (Tokyo Helicobacter pylori study group). Journal of Gastroenterology and Hepatology (Australia), 29(S4), 29-32. https://doi.org/10.1111/jgh.12796