Abstract
Aim: It is well established that people gain weight after smoking cessation; however, changes in cardiovascular risk factors and the estimated risk of coronary heart disease following smoking cessation have yet to be fully clarified. Methods: The participants were 1,995 Japanese male workers at 11 workplaces who participated continuously in the High-risk and Population Strategy for Occupational Health Promotion (HIPOPOHP) study. Participants with a smoking habit had cardiovascular risk factors measured at baseline and over a 4-yr period. Their estimated incidence risk of coronary heart disease was calculated by a formula based on a previous cohort study. Results: Successful abstainers who had stopped smoking for at least 6 months at the end of the follow-up period had weight gains of approximately 2 kg. These subjects had significant worsening of the following factors compared to continuing smokers: systolic and diastolic blood pressure, total cholesterol, triglyceride and fasting blood sugar levels. In contrast, HDL-cholesterol levels improved significantly. When the overall instantaneous incidence risk of coronary heart disease prior to smoking cessation was assumed to be 1.00, the estimated risk was 0.76 (95%CI: 0.68-0.85) in successful abstainers due mainly to smoking cessation, despite weight gain. Conclusion: Although smoking cessation leads to weight gain, the estimated risk of coronary heart disease was decreased markedly by smoking cessation.
| Original language | English |
|---|---|
| Pages (from-to) | 12-20 |
| Number of pages | 9 |
| Journal | Journal of Atherosclerosis and Thrombosis |
| Volume | 17 |
| Issue number | 1 |
| Publication status | Published - 2010 |
| Externally published | Yes |
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Keywords
- Blood pressure
- Cardiovascular disease
- Cholesterol
- Lifestyle modification
- Smoking cessation
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Internal Medicine
- Biochemistry, medical
Cite this
Changes in weight, cardiovascular risk factors and estimated risk of coronary heart disease following smoking cessation in Japanese male workers : HIPOP-OHP study. / Tamura, Unai; Tanaka, Taichiro; Okamura, Tomonori; Kadowaki, Takashi; Yamato, Hiroshi; Tanaka, Hideo; Nakamura, Masakazu; Okayama, Akira; Ueshima, Hirotsugu; Yamagata, Zentaro.
In: Journal of Atherosclerosis and Thrombosis, Vol. 17, No. 1, 2010, p. 12-20.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Changes in weight, cardiovascular risk factors and estimated risk of coronary heart disease following smoking cessation in Japanese male workers
T2 - HIPOP-OHP study
AU - Tamura, Unai
AU - Tanaka, Taichiro
AU - Okamura, Tomonori
AU - Kadowaki, Takashi
AU - Yamato, Hiroshi
AU - Tanaka, Hideo
AU - Nakamura, Masakazu
AU - Okayama, Akira
AU - Ueshima, Hirotsugu
AU - Yamagata, Zentaro
PY - 2010
Y1 - 2010
N2 - Aim: It is well established that people gain weight after smoking cessation; however, changes in cardiovascular risk factors and the estimated risk of coronary heart disease following smoking cessation have yet to be fully clarified. Methods: The participants were 1,995 Japanese male workers at 11 workplaces who participated continuously in the High-risk and Population Strategy for Occupational Health Promotion (HIPOPOHP) study. Participants with a smoking habit had cardiovascular risk factors measured at baseline and over a 4-yr period. Their estimated incidence risk of coronary heart disease was calculated by a formula based on a previous cohort study. Results: Successful abstainers who had stopped smoking for at least 6 months at the end of the follow-up period had weight gains of approximately 2 kg. These subjects had significant worsening of the following factors compared to continuing smokers: systolic and diastolic blood pressure, total cholesterol, triglyceride and fasting blood sugar levels. In contrast, HDL-cholesterol levels improved significantly. When the overall instantaneous incidence risk of coronary heart disease prior to smoking cessation was assumed to be 1.00, the estimated risk was 0.76 (95%CI: 0.68-0.85) in successful abstainers due mainly to smoking cessation, despite weight gain. Conclusion: Although smoking cessation leads to weight gain, the estimated risk of coronary heart disease was decreased markedly by smoking cessation.
AB - Aim: It is well established that people gain weight after smoking cessation; however, changes in cardiovascular risk factors and the estimated risk of coronary heart disease following smoking cessation have yet to be fully clarified. Methods: The participants were 1,995 Japanese male workers at 11 workplaces who participated continuously in the High-risk and Population Strategy for Occupational Health Promotion (HIPOPOHP) study. Participants with a smoking habit had cardiovascular risk factors measured at baseline and over a 4-yr period. Their estimated incidence risk of coronary heart disease was calculated by a formula based on a previous cohort study. Results: Successful abstainers who had stopped smoking for at least 6 months at the end of the follow-up period had weight gains of approximately 2 kg. These subjects had significant worsening of the following factors compared to continuing smokers: systolic and diastolic blood pressure, total cholesterol, triglyceride and fasting blood sugar levels. In contrast, HDL-cholesterol levels improved significantly. When the overall instantaneous incidence risk of coronary heart disease prior to smoking cessation was assumed to be 1.00, the estimated risk was 0.76 (95%CI: 0.68-0.85) in successful abstainers due mainly to smoking cessation, despite weight gain. Conclusion: Although smoking cessation leads to weight gain, the estimated risk of coronary heart disease was decreased markedly by smoking cessation.
KW - Blood pressure
KW - Cardiovascular disease
KW - Cholesterol
KW - Lifestyle modification
KW - Smoking cessation
UR - http://www.scopus.com/inward/record.url?scp=76249091209&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=76249091209&partnerID=8YFLogxK
M3 - Article
C2 - 20081325
AN - SCOPUS:76249091209
VL - 17
SP - 12
EP - 20
JO - Journal of Atherosclerosis and Thrombosis
JF - Journal of Atherosclerosis and Thrombosis
SN - 1340-3478
IS - 1
ER -