Changes of β-1,4-galactosyltransferase with the development of endometrial cancer

Kaneyuki Kubushiro, Jun Ma, Takeshi Fukuchi, Kouji Banno, Yuko Muramatsu, Katsumi Tsukazaki, Shiro Nozawa

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

To elucidate the mechanism of the type 2 carbohydrate chain accompanying the development of endometrial cancer, we studied the expression of β-1,4-galactosyltransferase (β-1,4GT) in normal endometrial and endometrial cancer tissues. An immunohistochemical study revealed that β-1,4GT was diffusely positive in the cytoplasm of endometrial cancer cells, and that the level of its expression was increased compared with that in normal endometrium. Also, β-1,4GT mRNA corresponding to 4.7 kb was very low in normal endometrium, while an intense signal was detected in endometrial cancer. Our results suggest that the increase of β-1,4GT contributes to the expression of the type 2 carbohydrate chain in endometrial cancer.

Original languageEnglish
Pages (from-to)211-214
Number of pages4
JournalGynecologic and Obstetric Investigation
Volume48
Issue number3
DOIs
Publication statusPublished - 1999

Keywords

  • Carbohydrate chain, type 2
  • Endometrial cancer
  • β-1,4-galactosyltransferase

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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