Changes of β-1,4-galactosyltransferase with the development of endometrial cancer

Kaneyuki Kubushiro, Jun Ma, Takeshi Fukuchi, Kouji Banno, Yuko Muramatsu, Katsumi Tsukazaki, Shiro Nozawa

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

To elucidate the mechanism of the type 2 carbohydrate chain accompanying the development of endometrial cancer, we studied the expression of β-1,4-galactosyltransferase (β-1,4GT) in normal endometrial and endometrial cancer tissues. An immunohistochemical study revealed that β-1,4GT was diffusely positive in the cytoplasm of endometrial cancer cells, and that the level of its expression was increased compared with that in normal endometrium. Also, β-1,4GT mRNA corresponding to 4.7 kb was very low in normal endometrium, while an intense signal was detected in endometrial cancer. Our results suggest that the increase of β-1,4GT contributes to the expression of the type 2 carbohydrate chain in endometrial cancer.

Original languageEnglish
Pages (from-to)211-214
Number of pages4
JournalGynecologic and Obstetric Investigation
Volume48
Issue number3
DOIs
Publication statusPublished - 1999

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Galactosyltransferases
Endometrial Neoplasms
Endometrium
Carbohydrates
Cytoplasm
Messenger RNA

Keywords

  • β-1,4-galactosyltransferase
  • Carbohydrate chain, type 2
  • Endometrial cancer

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Changes of β-1,4-galactosyltransferase with the development of endometrial cancer. / Kubushiro, Kaneyuki; Ma, Jun; Fukuchi, Takeshi; Banno, Kouji; Muramatsu, Yuko; Tsukazaki, Katsumi; Nozawa, Shiro.

In: Gynecologic and Obstetric Investigation, Vol. 48, No. 3, 1999, p. 211-214.

Research output: Contribution to journalArticle

Kubushiro, K, Ma, J, Fukuchi, T, Banno, K, Muramatsu, Y, Tsukazaki, K & Nozawa, S 1999, 'Changes of β-1,4-galactosyltransferase with the development of endometrial cancer', Gynecologic and Obstetric Investigation, vol. 48, no. 3, pp. 211-214. https://doi.org/10.1159/000010158
Kubushiro, Kaneyuki ; Ma, Jun ; Fukuchi, Takeshi ; Banno, Kouji ; Muramatsu, Yuko ; Tsukazaki, Katsumi ; Nozawa, Shiro. / Changes of β-1,4-galactosyltransferase with the development of endometrial cancer. In: Gynecologic and Obstetric Investigation. 1999 ; Vol. 48, No. 3. pp. 211-214.
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