Changing the Concept of Type 2 Diabetes: Beta Cell Workload Hypothesis Revisited

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Despite a number of innovations in anti-diabetic drugs and substantial improvement in diabetes care, the number of people with diabetes continues to increase, suggesting further need to explore novel approaches to prevent diabetes. Type 2 diabetes (T2DM) is characterized by beta cell dysfunction and insulin resistance. However, insulin resistance, usually a consequence of obesity, is often emphasized and the role of beta cell dysfunction in T2DM is less appreciated. OBJECTIVE AND RESULTS: This paper summarizes recent evidence showing the importance of beta cell dysfunction in T2DM and refines the "beta cell workload hypothesis", emphasizing the importance of beta cell preservation for the prevention and management of T2DM. CONCLUSION: It is hoped that this novel concept will foster a better understanding of the pathophysiology of T2DM by not only medical staff and patients with diabetes, but also the general population, and encourage more people to adhere to a healthy lifestyle, eventually resulting in "stopping diabetes".

Original languageEnglish
Pages (from-to)121-127
Number of pages7
JournalEndocrine, metabolic & immune disorders drug targets
Volume19
Issue number2
DOIs
Publication statusPublished - 2019 Jan 1

Fingerprint

Workload
Type 2 Diabetes Mellitus
Insulin Resistance
Medical Staff
Obesity
Pharmaceutical Preparations
Population

Keywords

  • beta cell
  • empowerment
  • insulin resistance
  • lifestyle modification
  • prevention.
  • Type 2 diabetes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy

Cite this

Changing the Concept of Type 2 Diabetes : Beta Cell Workload Hypothesis Revisited. / Saisho, Yoshifumi.

In: Endocrine, metabolic & immune disorders drug targets, Vol. 19, No. 2, 01.01.2019, p. 121-127.

Research output: Contribution to journalArticle

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