Characteristic immunophenotype of solid subtype component in lung adenocarcinoma

Teruhisa Takuwa, Genichiro Ishii, Kanji Nagai, Junji Yoshida, Mitsuyo Nishimura, Tomoyuki Hishida, Shinya Neri, Seiki Hasegawa, Atsushi Ochiai

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background. Lung adenocarcinomas represent a morphologically heterogeneous tumor composed of an admixture of different histologic subtypes (lepidic, papillary, acinar, and solid subtype). The presence of a solid subtype component is reported to be associated with a poorer prognosis. The aim of this study was to evaluate the characteristic immunophenotype of the solid subtype component compared with the immunophenotypes of other components. Methods. We analyzed the clinicopathological characteristics of stage I adenocarcinoma patientswith predominant solid subtype disease. Furthermore, we immunostained adenocarcinomaswith predominant lepidic, papillary, acinar, and solid subtype components (n = 23 each) for 10 molecular markers of tumor invasiveness and scored the results. Results. Patients showing predominance of the solid subtype component (solid subtype adenocarcinoma) had a poorer prognosis than those showing predominance of the lepidic, papillary, or acinar component. Lymphovascular invasion was more often detected in solid subtype tumors than in others. The solid subtype component showed a significantly stronger staining intensity of laminin-5 expression than the lepidic, papillary, and acinar components (P<0.001, P<0.001, and P = 0.016, respectively). The fibronectin and vimentin expression levels were also significantly higher in the solid subtype component than in other components. This immunostaining character was validated by using mixed-subtype adenocarcinomas containing all four components in the same tumor. Conclusions. This study concluded that the solid subtype component in lung adenocarcinomas exhibit the invasive immunophenotype, including increased laminin-5 expression, compared with the other components, which may be associated with a poorer prognosis.

Original languageEnglish
Pages (from-to)3943-3952
Number of pages10
JournalAnnals of Surgical Oncology
Volume19
Issue number12
DOIs
Publication statusPublished - 2012 Nov
Externally publishedYes

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Adenocarcinoma
Neoplasms
Vimentin
Tumor Biomarkers
Fibronectins
Staining and Labeling
Adenocarcinoma of lung
kalinin

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Takuwa, T., Ishii, G., Nagai, K., Yoshida, J., Nishimura, M., Hishida, T., ... Ochiai, A. (2012). Characteristic immunophenotype of solid subtype component in lung adenocarcinoma. Annals of Surgical Oncology, 19(12), 3943-3952. https://doi.org/10.1245/s10434-012-2428-x

Characteristic immunophenotype of solid subtype component in lung adenocarcinoma. / Takuwa, Teruhisa; Ishii, Genichiro; Nagai, Kanji; Yoshida, Junji; Nishimura, Mitsuyo; Hishida, Tomoyuki; Neri, Shinya; Hasegawa, Seiki; Ochiai, Atsushi.

In: Annals of Surgical Oncology, Vol. 19, No. 12, 11.2012, p. 3943-3952.

Research output: Contribution to journalArticle

Takuwa, T, Ishii, G, Nagai, K, Yoshida, J, Nishimura, M, Hishida, T, Neri, S, Hasegawa, S & Ochiai, A 2012, 'Characteristic immunophenotype of solid subtype component in lung adenocarcinoma', Annals of Surgical Oncology, vol. 19, no. 12, pp. 3943-3952. https://doi.org/10.1245/s10434-012-2428-x
Takuwa, Teruhisa ; Ishii, Genichiro ; Nagai, Kanji ; Yoshida, Junji ; Nishimura, Mitsuyo ; Hishida, Tomoyuki ; Neri, Shinya ; Hasegawa, Seiki ; Ochiai, Atsushi. / Characteristic immunophenotype of solid subtype component in lung adenocarcinoma. In: Annals of Surgical Oncology. 2012 ; Vol. 19, No. 12. pp. 3943-3952.
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AU - Takuwa, Teruhisa

AU - Ishii, Genichiro

AU - Nagai, Kanji

AU - Yoshida, Junji

AU - Nishimura, Mitsuyo

AU - Hishida, Tomoyuki

AU - Neri, Shinya

AU - Hasegawa, Seiki

AU - Ochiai, Atsushi

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N2 - Background. Lung adenocarcinomas represent a morphologically heterogeneous tumor composed of an admixture of different histologic subtypes (lepidic, papillary, acinar, and solid subtype). The presence of a solid subtype component is reported to be associated with a poorer prognosis. The aim of this study was to evaluate the characteristic immunophenotype of the solid subtype component compared with the immunophenotypes of other components. Methods. We analyzed the clinicopathological characteristics of stage I adenocarcinoma patientswith predominant solid subtype disease. Furthermore, we immunostained adenocarcinomaswith predominant lepidic, papillary, acinar, and solid subtype components (n = 23 each) for 10 molecular markers of tumor invasiveness and scored the results. Results. Patients showing predominance of the solid subtype component (solid subtype adenocarcinoma) had a poorer prognosis than those showing predominance of the lepidic, papillary, or acinar component. Lymphovascular invasion was more often detected in solid subtype tumors than in others. The solid subtype component showed a significantly stronger staining intensity of laminin-5 expression than the lepidic, papillary, and acinar components (P<0.001, P<0.001, and P = 0.016, respectively). The fibronectin and vimentin expression levels were also significantly higher in the solid subtype component than in other components. This immunostaining character was validated by using mixed-subtype adenocarcinomas containing all four components in the same tumor. Conclusions. This study concluded that the solid subtype component in lung adenocarcinomas exhibit the invasive immunophenotype, including increased laminin-5 expression, compared with the other components, which may be associated with a poorer prognosis.

AB - Background. Lung adenocarcinomas represent a morphologically heterogeneous tumor composed of an admixture of different histologic subtypes (lepidic, papillary, acinar, and solid subtype). The presence of a solid subtype component is reported to be associated with a poorer prognosis. The aim of this study was to evaluate the characteristic immunophenotype of the solid subtype component compared with the immunophenotypes of other components. Methods. We analyzed the clinicopathological characteristics of stage I adenocarcinoma patientswith predominant solid subtype disease. Furthermore, we immunostained adenocarcinomaswith predominant lepidic, papillary, acinar, and solid subtype components (n = 23 each) for 10 molecular markers of tumor invasiveness and scored the results. Results. Patients showing predominance of the solid subtype component (solid subtype adenocarcinoma) had a poorer prognosis than those showing predominance of the lepidic, papillary, or acinar component. Lymphovascular invasion was more often detected in solid subtype tumors than in others. The solid subtype component showed a significantly stronger staining intensity of laminin-5 expression than the lepidic, papillary, and acinar components (P<0.001, P<0.001, and P = 0.016, respectively). The fibronectin and vimentin expression levels were also significantly higher in the solid subtype component than in other components. This immunostaining character was validated by using mixed-subtype adenocarcinomas containing all four components in the same tumor. Conclusions. This study concluded that the solid subtype component in lung adenocarcinomas exhibit the invasive immunophenotype, including increased laminin-5 expression, compared with the other components, which may be associated with a poorer prognosis.

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