Characteristics and mechanism of myocardium tissue laser ablation: In-vitro study for transmyocardial laser revascularization

Shunichi Sato, Tomoaki Shimada, Makoto Ogura, Miya Ishihara, Tsunenori Arai, Takemi Matsui, Akira Kurita, Minoru Obara, Makoto Kikuchi, Hitoshi Wakisaka, Hiroshi Ashida

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

To investigate the optimum laser condition for transmyocardial laser revascularization (TMLR), ablation characteristics of porcine myocardium tissue have been measured in vitro in the spectral region from UV to near IR (230-1064 nm). In experiments, a nanosecond, tunable optical parametric oscillator (OPO) and a Q-switched Nd:YAG laser (the fundamental band and its 2nd, 3rd, and 4th harmonics) were used for ablation. Measurement of ablation hole depth and diameter, and histological analysis with an optical microscope were performed. It was found that the ablation efficiency increased and the thermal damage thickness of the tissue decreased with decreasing the wavelength. However, at relatively high fluences (approximately 5 J/cm2), unexpected deep ablation was obtained with a 1064-nm laser light, where not thermal but acoustic damage was observed near the walls of the ablation holes. Because intense laser-induced plasma was observed in this case, the shock wave would contribute to removal and/or damage of the tissue.

Original languageEnglish
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
PublisherSociety of Photo-Optical Instrumentation Engineers
Pages132-137
Number of pages6
Volume3885
Publication statusPublished - 2000
Externally publishedYes
EventHigh-Power Laser Ablation II - Osaka, Jpn
Duration: 1999 Nov 11999 Nov 5

Other

OtherHigh-Power Laser Ablation II
CityOsaka, Jpn
Period99/11/199/11/5

Fingerprint

myocardium
Laser ablation
Ablation
laser ablation
ablation
Tissue
Lasers
lasers
damage
Optical parametric oscillators
Q switched lasers
parametric amplifiers
optical microscopes
Shock waves
YAG lasers
shock waves
fluence
Microscopes
Acoustics
Plasmas

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Sato, S., Shimada, T., Ogura, M., Ishihara, M., Arai, T., Matsui, T., ... Ashida, H. (2000). Characteristics and mechanism of myocardium tissue laser ablation: In-vitro study for transmyocardial laser revascularization. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 3885, pp. 132-137). Society of Photo-Optical Instrumentation Engineers.

Characteristics and mechanism of myocardium tissue laser ablation : In-vitro study for transmyocardial laser revascularization. / Sato, Shunichi; Shimada, Tomoaki; Ogura, Makoto; Ishihara, Miya; Arai, Tsunenori; Matsui, Takemi; Kurita, Akira; Obara, Minoru; Kikuchi, Makoto; Wakisaka, Hitoshi; Ashida, Hiroshi.

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3885 Society of Photo-Optical Instrumentation Engineers, 2000. p. 132-137.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Sato, S, Shimada, T, Ogura, M, Ishihara, M, Arai, T, Matsui, T, Kurita, A, Obara, M, Kikuchi, M, Wakisaka, H & Ashida, H 2000, Characteristics and mechanism of myocardium tissue laser ablation: In-vitro study for transmyocardial laser revascularization. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 3885, Society of Photo-Optical Instrumentation Engineers, pp. 132-137, High-Power Laser Ablation II, Osaka, Jpn, 99/11/1.
Sato S, Shimada T, Ogura M, Ishihara M, Arai T, Matsui T et al. Characteristics and mechanism of myocardium tissue laser ablation: In-vitro study for transmyocardial laser revascularization. In Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3885. Society of Photo-Optical Instrumentation Engineers. 2000. p. 132-137
Sato, Shunichi ; Shimada, Tomoaki ; Ogura, Makoto ; Ishihara, Miya ; Arai, Tsunenori ; Matsui, Takemi ; Kurita, Akira ; Obara, Minoru ; Kikuchi, Makoto ; Wakisaka, Hitoshi ; Ashida, Hiroshi. / Characteristics and mechanism of myocardium tissue laser ablation : In-vitro study for transmyocardial laser revascularization. Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3885 Society of Photo-Optical Instrumentation Engineers, 2000. pp. 132-137
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AU - Arai, Tsunenori

AU - Matsui, Takemi

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AB - To investigate the optimum laser condition for transmyocardial laser revascularization (TMLR), ablation characteristics of porcine myocardium tissue have been measured in vitro in the spectral region from UV to near IR (230-1064 nm). In experiments, a nanosecond, tunable optical parametric oscillator (OPO) and a Q-switched Nd:YAG laser (the fundamental band and its 2nd, 3rd, and 4th harmonics) were used for ablation. Measurement of ablation hole depth and diameter, and histological analysis with an optical microscope were performed. It was found that the ablation efficiency increased and the thermal damage thickness of the tissue decreased with decreasing the wavelength. However, at relatively high fluences (approximately 5 J/cm2), unexpected deep ablation was obtained with a 1064-nm laser light, where not thermal but acoustic damage was observed near the walls of the ablation holes. Because intense laser-induced plasma was observed in this case, the shock wave would contribute to removal and/or damage of the tissue.

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