Characteristics of gastric stump cancer

A single hospital retrospective analysis of 262 patients

Tomoyuki Irino, Naoki Hiki, Manabu Ohashi, Souya Nunobe, Masanori Tokunaga, Takeshi Sano, Toshiharu Yamaguchi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background Owing to its relative rarity, the characteristics of gastric stump cancer (GSC) have not been fully understood. In this study, we clarified the detailed characteristics from a large cohort of GSC patients. Patients and methods For this retrospective cohort study from 1 hospital in Japan, we recruited 262 GSC patients who underwent surgery for GSC between 1984 and 2012. GSC was defined in accordance with Japanese Gastric Cancer Association. Stage was categorized in accordance with the 7th TNM classification for primary gastric cancer. Results Although the time interval between the primary and second operations differed significantly depending on the primary disease (34.3 years for benign vs 9.9 years for malignant on average), it did not influence survival. The 5-year overall survival rates of patients with N0, N1, N2, and N3 were 70.4%, 27.7%, 21.8%, and 6.4%, respectively, whereas the rates for those with stage I, II, III, and IV were 77.8%, 37.4%, 18.6%, and 10.5%, respectively. Recurrence in the peritoneum was the most common pattern, followed by recurrence in the local region or lymph nodes. The Cox proportional hazard model demonstrated that age > 65, T stage, N stage, and tumor histology were significant independent prognostic factors for survival, whereas neither primary disease nor primary anastomosis type significantly impacted survival. Conclusion Neither primary disease nor anastomosis type affected survival significantly, despite significant differences in their characteristics. In addition, the time interval between the primary and second surgery did not impact survival.

Original languageEnglish
Pages (from-to)1539-1547
Number of pages9
JournalSurgery (United States)
Volume159
Issue number6
DOIs
Publication statusPublished - 2016 Jun 1
Externally publishedYes

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Gastric Stump
Stomach Neoplasms
Survival
Recurrence
Neoplasm Staging
Peritoneum
Proportional Hazards Models
Histology
Japan
Cohort Studies
Survival Rate
Retrospective Studies
Lymph Nodes

ASJC Scopus subject areas

  • Surgery

Cite this

Irino, T., Hiki, N., Ohashi, M., Nunobe, S., Tokunaga, M., Sano, T., & Yamaguchi, T. (2016). Characteristics of gastric stump cancer: A single hospital retrospective analysis of 262 patients. Surgery (United States), 159(6), 1539-1547. https://doi.org/10.1016/j.surg.2016.01.003

Characteristics of gastric stump cancer : A single hospital retrospective analysis of 262 patients. / Irino, Tomoyuki; Hiki, Naoki; Ohashi, Manabu; Nunobe, Souya; Tokunaga, Masanori; Sano, Takeshi; Yamaguchi, Toshiharu.

In: Surgery (United States), Vol. 159, No. 6, 01.06.2016, p. 1539-1547.

Research output: Contribution to journalArticle

Irino, T, Hiki, N, Ohashi, M, Nunobe, S, Tokunaga, M, Sano, T & Yamaguchi, T 2016, 'Characteristics of gastric stump cancer: A single hospital retrospective analysis of 262 patients', Surgery (United States), vol. 159, no. 6, pp. 1539-1547. https://doi.org/10.1016/j.surg.2016.01.003
Irino, Tomoyuki ; Hiki, Naoki ; Ohashi, Manabu ; Nunobe, Souya ; Tokunaga, Masanori ; Sano, Takeshi ; Yamaguchi, Toshiharu. / Characteristics of gastric stump cancer : A single hospital retrospective analysis of 262 patients. In: Surgery (United States). 2016 ; Vol. 159, No. 6. pp. 1539-1547.
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AB - Background Owing to its relative rarity, the characteristics of gastric stump cancer (GSC) have not been fully understood. In this study, we clarified the detailed characteristics from a large cohort of GSC patients. Patients and methods For this retrospective cohort study from 1 hospital in Japan, we recruited 262 GSC patients who underwent surgery for GSC between 1984 and 2012. GSC was defined in accordance with Japanese Gastric Cancer Association. Stage was categorized in accordance with the 7th TNM classification for primary gastric cancer. Results Although the time interval between the primary and second operations differed significantly depending on the primary disease (34.3 years for benign vs 9.9 years for malignant on average), it did not influence survival. The 5-year overall survival rates of patients with N0, N1, N2, and N3 were 70.4%, 27.7%, 21.8%, and 6.4%, respectively, whereas the rates for those with stage I, II, III, and IV were 77.8%, 37.4%, 18.6%, and 10.5%, respectively. Recurrence in the peritoneum was the most common pattern, followed by recurrence in the local region or lymph nodes. The Cox proportional hazard model demonstrated that age > 65, T stage, N stage, and tumor histology were significant independent prognostic factors for survival, whereas neither primary disease nor primary anastomosis type significantly impacted survival. Conclusion Neither primary disease nor anastomosis type affected survival significantly, despite significant differences in their characteristics. In addition, the time interval between the primary and second surgery did not impact survival.

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