Characteristics of glioma stem cells

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The cancer stem cell theory postulates that tumors are sustained by a select cell population with specific features, such as self-renewal ability and the capacity to give rise to a heterogeneous mass of tumor cells. The existence of such cells has been demonstrated for glioblastoma, with these cells being referred to as glioma stem cells (GSCs). Glioblastomas are notoriously heterogeneous tumors, however, and the isolation and characterization of their stem cells will require further investigations. Furthermore, the lack of unequivocal markers for GSCs and a partial overlap in characteristics with other cells often lead to confusion. Here, we review the characteristics necessary for a glioma cell to be considered a stem cell, and we adopt our murine glioblastoma model based on genetically modified neural stem cells to illustrate and discuss the GSC concept.

Original languageEnglish
Pages (from-to)209-214
Number of pages6
JournalBrain Tumor Pathology
Volume30
Issue number4
DOIs
Publication statusPublished - 2013 Oct

Fingerprint

Glioma
Stem Cells
Glioblastoma
Neoplasms
Neural Stem Cells
Neoplastic Stem Cells
Population

Keywords

  • Cancer stem cell (CSC)
  • Glioma cell of origin
  • Glioma stem cell (GSC)
  • Glioma-initiating cell (GIC)

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Clinical Neurology

Cite this

Characteristics of glioma stem cells. / Sampetrean, Oltea; Saya, Hideyuki.

In: Brain Tumor Pathology, Vol. 30, No. 4, 10.2013, p. 209-214.

Research output: Contribution to journalArticle

@article{618b2dfa329f4f55bf059246c9bb3d3f,
title = "Characteristics of glioma stem cells",
abstract = "The cancer stem cell theory postulates that tumors are sustained by a select cell population with specific features, such as self-renewal ability and the capacity to give rise to a heterogeneous mass of tumor cells. The existence of such cells has been demonstrated for glioblastoma, with these cells being referred to as glioma stem cells (GSCs). Glioblastomas are notoriously heterogeneous tumors, however, and the isolation and characterization of their stem cells will require further investigations. Furthermore, the lack of unequivocal markers for GSCs and a partial overlap in characteristics with other cells often lead to confusion. Here, we review the characteristics necessary for a glioma cell to be considered a stem cell, and we adopt our murine glioblastoma model based on genetically modified neural stem cells to illustrate and discuss the GSC concept.",
keywords = "Cancer stem cell (CSC), Glioma cell of origin, Glioma stem cell (GSC), Glioma-initiating cell (GIC)",
author = "Oltea Sampetrean and Hideyuki Saya",
year = "2013",
month = "10",
doi = "10.1007/s10014-013-0141-5",
language = "English",
volume = "30",
pages = "209--214",
journal = "Brain Tumor Pathology",
issn = "1433-7398",
publisher = "Springer Japan",
number = "4",

}

TY - JOUR

T1 - Characteristics of glioma stem cells

AU - Sampetrean, Oltea

AU - Saya, Hideyuki

PY - 2013/10

Y1 - 2013/10

N2 - The cancer stem cell theory postulates that tumors are sustained by a select cell population with specific features, such as self-renewal ability and the capacity to give rise to a heterogeneous mass of tumor cells. The existence of such cells has been demonstrated for glioblastoma, with these cells being referred to as glioma stem cells (GSCs). Glioblastomas are notoriously heterogeneous tumors, however, and the isolation and characterization of their stem cells will require further investigations. Furthermore, the lack of unequivocal markers for GSCs and a partial overlap in characteristics with other cells often lead to confusion. Here, we review the characteristics necessary for a glioma cell to be considered a stem cell, and we adopt our murine glioblastoma model based on genetically modified neural stem cells to illustrate and discuss the GSC concept.

AB - The cancer stem cell theory postulates that tumors are sustained by a select cell population with specific features, such as self-renewal ability and the capacity to give rise to a heterogeneous mass of tumor cells. The existence of such cells has been demonstrated for glioblastoma, with these cells being referred to as glioma stem cells (GSCs). Glioblastomas are notoriously heterogeneous tumors, however, and the isolation and characterization of their stem cells will require further investigations. Furthermore, the lack of unequivocal markers for GSCs and a partial overlap in characteristics with other cells often lead to confusion. Here, we review the characteristics necessary for a glioma cell to be considered a stem cell, and we adopt our murine glioblastoma model based on genetically modified neural stem cells to illustrate and discuss the GSC concept.

KW - Cancer stem cell (CSC)

KW - Glioma cell of origin

KW - Glioma stem cell (GSC)

KW - Glioma-initiating cell (GIC)

UR - http://www.scopus.com/inward/record.url?scp=84887215221&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84887215221&partnerID=8YFLogxK

U2 - 10.1007/s10014-013-0141-5

DO - 10.1007/s10014-013-0141-5

M3 - Article

VL - 30

SP - 209

EP - 214

JO - Brain Tumor Pathology

JF - Brain Tumor Pathology

SN - 1433-7398

IS - 4

ER -