Characteristics of loss of heterozygosity in large cell neuroendocrine carcinomas of the lung and small cell lung carcinomas

Tomoyo Takeuchi, Yuko Minami, Tatsuo Iijima, Toru Kameya, Hisao Asamura, Masayuki Noguchi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Large cell neuroendocrine carcinoma (LCNEC) of the lung is a new entity. Besides morphological characteristics, its molecular biological features have been investigated by many researchers and compared to those of other neuroendocrine carcinomas, small cell lung carcinoma (SCLC) and carcinoid tumor (CT). However, there are few reports that show the significantly different genetic characteristics between them. The purpose of the present paper was to study the frequency of loss of heterozygosity (LOH) at chromosome 3p (3p14.2) in 38 neuroendocrine carcinomas of the lung (13 LCNEC, 11 SCLC and 14 CT) and 10 large cell carcinomas (LCC). The frequencies of LOH at 3p14.2 were 69.2% in LCNEC, 81.8% in SCLC, 50.0% in LCC and 7.14% in CT. Those at 22q13.3 were 30.8% in LCNEC, 72.7% in SCLC, 45.5% in LCC and 7.14% in CT. In particular, the frequency of SCLC with LOH at both 3p14.2 and 22q13.3 (63.6%) was significantly higher than that of LCNEC (15.4%). LCNEC and SCLC had different characteristics of LOH patterns at 3p14.2 and 22q13.3. The combined analysis of the LOH at 3p14.2 and 22q13.3 is thought to be useful for differential diagnosis between LCNEC and SCLC.

Original languageEnglish
Pages (from-to)434-439
Number of pages6
JournalPathology International
Volume56
Issue number8
DOIs
Publication statusPublished - 2006 Aug
Externally publishedYes

Fingerprint

Neuroendocrine Carcinoma
Large Cell Carcinoma
Loss of Heterozygosity
Small Cell Lung Carcinoma
Lung
Carcinoid Tumor
Differential Diagnosis
Chromosomes
Research Personnel

Keywords

  • 22q13.3
  • 3p14.2
  • Large cell neuroendocrine carcinoma
  • Loss of heterozygosity
  • Small cell lung carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Characteristics of loss of heterozygosity in large cell neuroendocrine carcinomas of the lung and small cell lung carcinomas. / Takeuchi, Tomoyo; Minami, Yuko; Iijima, Tatsuo; Kameya, Toru; Asamura, Hisao; Noguchi, Masayuki.

In: Pathology International, Vol. 56, No. 8, 08.2006, p. 434-439.

Research output: Contribution to journalArticle

Takeuchi, Tomoyo ; Minami, Yuko ; Iijima, Tatsuo ; Kameya, Toru ; Asamura, Hisao ; Noguchi, Masayuki. / Characteristics of loss of heterozygosity in large cell neuroendocrine carcinomas of the lung and small cell lung carcinomas. In: Pathology International. 2006 ; Vol. 56, No. 8. pp. 434-439.
@article{37a9f72fda994e24b6db5599a61b7191,
title = "Characteristics of loss of heterozygosity in large cell neuroendocrine carcinomas of the lung and small cell lung carcinomas",
abstract = "Large cell neuroendocrine carcinoma (LCNEC) of the lung is a new entity. Besides morphological characteristics, its molecular biological features have been investigated by many researchers and compared to those of other neuroendocrine carcinomas, small cell lung carcinoma (SCLC) and carcinoid tumor (CT). However, there are few reports that show the significantly different genetic characteristics between them. The purpose of the present paper was to study the frequency of loss of heterozygosity (LOH) at chromosome 3p (3p14.2) in 38 neuroendocrine carcinomas of the lung (13 LCNEC, 11 SCLC and 14 CT) and 10 large cell carcinomas (LCC). The frequencies of LOH at 3p14.2 were 69.2{\%} in LCNEC, 81.8{\%} in SCLC, 50.0{\%} in LCC and 7.14{\%} in CT. Those at 22q13.3 were 30.8{\%} in LCNEC, 72.7{\%} in SCLC, 45.5{\%} in LCC and 7.14{\%} in CT. In particular, the frequency of SCLC with LOH at both 3p14.2 and 22q13.3 (63.6{\%}) was significantly higher than that of LCNEC (15.4{\%}). LCNEC and SCLC had different characteristics of LOH patterns at 3p14.2 and 22q13.3. The combined analysis of the LOH at 3p14.2 and 22q13.3 is thought to be useful for differential diagnosis between LCNEC and SCLC.",
keywords = "22q13.3, 3p14.2, Large cell neuroendocrine carcinoma, Loss of heterozygosity, Small cell lung carcinoma",
author = "Tomoyo Takeuchi and Yuko Minami and Tatsuo Iijima and Toru Kameya and Hisao Asamura and Masayuki Noguchi",
year = "2006",
month = "8",
doi = "10.1111/j.1440-1827.2006.01985.x",
language = "English",
volume = "56",
pages = "434--439",
journal = "Pathology International",
issn = "1320-5463",
publisher = "Wiley-Blackwell",
number = "8",

}

TY - JOUR

T1 - Characteristics of loss of heterozygosity in large cell neuroendocrine carcinomas of the lung and small cell lung carcinomas

AU - Takeuchi, Tomoyo

AU - Minami, Yuko

AU - Iijima, Tatsuo

AU - Kameya, Toru

AU - Asamura, Hisao

AU - Noguchi, Masayuki

PY - 2006/8

Y1 - 2006/8

N2 - Large cell neuroendocrine carcinoma (LCNEC) of the lung is a new entity. Besides morphological characteristics, its molecular biological features have been investigated by many researchers and compared to those of other neuroendocrine carcinomas, small cell lung carcinoma (SCLC) and carcinoid tumor (CT). However, there are few reports that show the significantly different genetic characteristics between them. The purpose of the present paper was to study the frequency of loss of heterozygosity (LOH) at chromosome 3p (3p14.2) in 38 neuroendocrine carcinomas of the lung (13 LCNEC, 11 SCLC and 14 CT) and 10 large cell carcinomas (LCC). The frequencies of LOH at 3p14.2 were 69.2% in LCNEC, 81.8% in SCLC, 50.0% in LCC and 7.14% in CT. Those at 22q13.3 were 30.8% in LCNEC, 72.7% in SCLC, 45.5% in LCC and 7.14% in CT. In particular, the frequency of SCLC with LOH at both 3p14.2 and 22q13.3 (63.6%) was significantly higher than that of LCNEC (15.4%). LCNEC and SCLC had different characteristics of LOH patterns at 3p14.2 and 22q13.3. The combined analysis of the LOH at 3p14.2 and 22q13.3 is thought to be useful for differential diagnosis between LCNEC and SCLC.

AB - Large cell neuroendocrine carcinoma (LCNEC) of the lung is a new entity. Besides morphological characteristics, its molecular biological features have been investigated by many researchers and compared to those of other neuroendocrine carcinomas, small cell lung carcinoma (SCLC) and carcinoid tumor (CT). However, there are few reports that show the significantly different genetic characteristics between them. The purpose of the present paper was to study the frequency of loss of heterozygosity (LOH) at chromosome 3p (3p14.2) in 38 neuroendocrine carcinomas of the lung (13 LCNEC, 11 SCLC and 14 CT) and 10 large cell carcinomas (LCC). The frequencies of LOH at 3p14.2 were 69.2% in LCNEC, 81.8% in SCLC, 50.0% in LCC and 7.14% in CT. Those at 22q13.3 were 30.8% in LCNEC, 72.7% in SCLC, 45.5% in LCC and 7.14% in CT. In particular, the frequency of SCLC with LOH at both 3p14.2 and 22q13.3 (63.6%) was significantly higher than that of LCNEC (15.4%). LCNEC and SCLC had different characteristics of LOH patterns at 3p14.2 and 22q13.3. The combined analysis of the LOH at 3p14.2 and 22q13.3 is thought to be useful for differential diagnosis between LCNEC and SCLC.

KW - 22q13.3

KW - 3p14.2

KW - Large cell neuroendocrine carcinoma

KW - Loss of heterozygosity

KW - Small cell lung carcinoma

UR - http://www.scopus.com/inward/record.url?scp=33745811333&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745811333&partnerID=8YFLogxK

U2 - 10.1111/j.1440-1827.2006.01985.x

DO - 10.1111/j.1440-1827.2006.01985.x

M3 - Article

C2 - 16872437

AN - SCOPUS:33745811333

VL - 56

SP - 434

EP - 439

JO - Pathology International

JF - Pathology International

SN - 1320-5463

IS - 8

ER -