Abstract
We investigated the influences on the smooth muscle cells of temporally heated arterial walls in both ex vivo and in vitro study to determine the optimum heat parameter of novel short-term thermal angioplasty, Photo-thermo Dynamic Balloon Angioplasty (PTDBA). Arterial heating dilatation was performed by the prototype PTDBA balloon ex vivo. We found that the smooth muscle cells in the vessel wall were stretch-fixed after the heating dilatation ex vivo. The stretch-fixing rate of these cells was increased with the temperature rise in the balloon of PTDBA from 60 °C to 70 °C. We measured the proliferation rate of the stretch-fixed smooth muscle cells, which were extracted from porcine arteries, on specially designed culture equipment in vitro. It was observed that the proliferation rate was inhibited at 20 % stretching compared to 10 % stretching. We think the stretch-fixing of the smooth muscle cells might not be harmful for PTDBA performances.
| Original language | English |
|---|---|
| Title of host publication | 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10 |
| Pages | 6706-6708 |
| Number of pages | 3 |
| DOIs | |
| Publication status | Published - 2010 |
| Event | 2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10 - Buenos Aires, Argentina Duration: 2010 Aug 31 → 2010 Sep 4 |
Other
| Other | 2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10 |
|---|---|
| Country | Argentina |
| City | Buenos Aires |
| Period | 10/8/31 → 10/9/4 |
Fingerprint
ASJC Scopus subject areas
- Biomedical Engineering
Cite this
Characteristics of smooth muscle cell's shape and proliferation rate in novel short-term thermal angioplasty ex vivo and in vitro. / Kunio, Mie; Shimazaki, Natsumi; Ito, Arisa; Hayashi, Tomoaki; Arai, Tsunenori.
2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10. 2010. p. 6706-6708 5626248.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Characteristics of smooth muscle cell's shape and proliferation rate in novel short-term thermal angioplasty ex vivo and in vitro
AU - Kunio, Mie
AU - Shimazaki, Natsumi
AU - Ito, Arisa
AU - Hayashi, Tomoaki
AU - Arai, Tsunenori
PY - 2010
Y1 - 2010
N2 - We investigated the influences on the smooth muscle cells of temporally heated arterial walls in both ex vivo and in vitro study to determine the optimum heat parameter of novel short-term thermal angioplasty, Photo-thermo Dynamic Balloon Angioplasty (PTDBA). Arterial heating dilatation was performed by the prototype PTDBA balloon ex vivo. We found that the smooth muscle cells in the vessel wall were stretch-fixed after the heating dilatation ex vivo. The stretch-fixing rate of these cells was increased with the temperature rise in the balloon of PTDBA from 60 °C to 70 °C. We measured the proliferation rate of the stretch-fixed smooth muscle cells, which were extracted from porcine arteries, on specially designed culture equipment in vitro. It was observed that the proliferation rate was inhibited at 20 % stretching compared to 10 % stretching. We think the stretch-fixing of the smooth muscle cells might not be harmful for PTDBA performances.
AB - We investigated the influences on the smooth muscle cells of temporally heated arterial walls in both ex vivo and in vitro study to determine the optimum heat parameter of novel short-term thermal angioplasty, Photo-thermo Dynamic Balloon Angioplasty (PTDBA). Arterial heating dilatation was performed by the prototype PTDBA balloon ex vivo. We found that the smooth muscle cells in the vessel wall were stretch-fixed after the heating dilatation ex vivo. The stretch-fixing rate of these cells was increased with the temperature rise in the balloon of PTDBA from 60 °C to 70 °C. We measured the proliferation rate of the stretch-fixed smooth muscle cells, which were extracted from porcine arteries, on specially designed culture equipment in vitro. It was observed that the proliferation rate was inhibited at 20 % stretching compared to 10 % stretching. We think the stretch-fixing of the smooth muscle cells might not be harmful for PTDBA performances.
UR - http://www.scopus.com/inward/record.url?scp=78650817215&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78650817215&partnerID=8YFLogxK
U2 - 10.1109/IEMBS.2010.5626248
DO - 10.1109/IEMBS.2010.5626248
M3 - Conference contribution
C2 - 21096081
AN - SCOPUS:78650817215
SN - 9781424441235
SP - 6706
EP - 6708
BT - 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
ER -