Characteristics of subcortical infarction due to distal MCA penetrating artery occlusion

Kentaro Suzuki, Junya Aoki, Yoshio Tanizaki, Yuki Sakamoto, Satoshi Takahashi, Arata Abe, Hiroaki Kimura, Tadashige Kano, Satoshi Suda, Yasuhiro Nishiyama, Kazunori Akaji, Ban Mihara, Kazumi Kimura

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective Isolated deep subcortical infarcts develop as a result of occlusion of the penetrating arteries from the internal carotid artery (ICA) and the proximal (M1) and distal middle cerebral artery (MCA). However, the clinical and neuroimaging characteristics of infarcts due to the occlusion of the distal MCA penetrating artery are unclear. Methods Consecutive patients with ischemic stroke or transient ischemic attack with magnetic resonance imaging (MRI) performed within 2 days of onset were studied retrospectively. Using coronal MRI data, isolated deep subcortical infarcts were classified into two groups: 1) proximal group, described as being longer than they are wide, which were expected to be related to the occlusion of the ICA or M1 penetrating artery; and 2) distal group, described as oblong, which were expected to be associated with the occlusion of penetrating arteries from the distal MCA (M2/M3/M4). Results A total of 653 consecutive acute ischemic stroke patients (proximal group, 50 [7.7%]; distal group, 14 [2.1%]) were enrolled. Baseline clinical characteristics were not different between the 2 groups. Modified Rankin Scale scores were lower in the distal group than in the proximal group 3 months after stroke onset (1.43 ± 0.36 vs. 2.26 ± 1.35, p = 0.023). We measured the lengths of the infarcts in the X and Y directions using axial MRI. The X/Y ratio was larger in the distal group than in the proximal group (1.3 ± 0.6 vs. 0.7 ± 0.2, p < 0.01), which indicated that distal MCA penetrating artery infarcts appear more oblong on axial MRI. Conclusions One cause for deep subcortical infarction is the occlusion of the distal MCA penetrating arteries, which occurs in 22% of patients with deep subcortical infarctions. These patients had better clinical outcomes than those with ICA and M1 penetrating artery infarctions. Distal MCA penetrating artery infarctions appear oblong on axial MRI.

Original languageEnglish
Pages (from-to)160-164
Number of pages5
JournalJournal of the Neurological Sciences
Volume368
DOIs
Publication statusPublished - 2016 Sep 15

Keywords

  • Clinical outcome
  • Diffusion-weighted imaging
  • Infarct evolution
  • Ischemic stroke

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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