Characteristics of subcortical infarction due to distal MCA penetrating artery occlusion

Kentaro Suzuki, Junya Aoki, Yoshio Tanizaki, Yuki Sakamoto, Satoshi Takahashi, Arata Abe, Hiroaki Kimura, Tadashige Kano, Satoshi Suda, Yasuhiro Nishiyama, Kazunori Akaji, Ban Mihara, Kazumi Kimura

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective Isolated deep subcortical infarcts develop as a result of occlusion of the penetrating arteries from the internal carotid artery (ICA) and the proximal (M1) and distal middle cerebral artery (MCA). However, the clinical and neuroimaging characteristics of infarcts due to the occlusion of the distal MCA penetrating artery are unclear. Methods Consecutive patients with ischemic stroke or transient ischemic attack with magnetic resonance imaging (MRI) performed within 2 days of onset were studied retrospectively. Using coronal MRI data, isolated deep subcortical infarcts were classified into two groups: 1) proximal group, described as being longer than they are wide, which were expected to be related to the occlusion of the ICA or M1 penetrating artery; and 2) distal group, described as oblong, which were expected to be associated with the occlusion of penetrating arteries from the distal MCA (M2/M3/M4). Results A total of 653 consecutive acute ischemic stroke patients (proximal group, 50 [7.7%]; distal group, 14 [2.1%]) were enrolled. Baseline clinical characteristics were not different between the 2 groups. Modified Rankin Scale scores were lower in the distal group than in the proximal group 3 months after stroke onset (1.43 ± 0.36 vs. 2.26 ± 1.35, p = 0.023). We measured the lengths of the infarcts in the X and Y directions using axial MRI. The X/Y ratio was larger in the distal group than in the proximal group (1.3 ± 0.6 vs. 0.7 ± 0.2, p 

Original languageEnglish
Pages (from-to)160-164
Number of pages5
JournalJournal of the Neurological Sciences
Volume368
DOIs
Publication statusPublished - 2016 Sep 15

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Cerebral Infarction
Middle Cerebral Artery
Arteries
Stroke
Magnetic Resonance Imaging
Internal Carotid Artery
Middle Cerebral Artery Infarction
Transient Ischemic Attack
Neuroimaging

Keywords

  • Clinical outcome
  • Diffusion-weighted imaging
  • Infarct evolution
  • Ischemic stroke

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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Characteristics of subcortical infarction due to distal MCA penetrating artery occlusion. / Suzuki, Kentaro; Aoki, Junya; Tanizaki, Yoshio; Sakamoto, Yuki; Takahashi, Satoshi; Abe, Arata; Kimura, Hiroaki; Kano, Tadashige; Suda, Satoshi; Nishiyama, Yasuhiro; Akaji, Kazunori; Mihara, Ban; Kimura, Kazumi.

In: Journal of the Neurological Sciences, Vol. 368, 15.09.2016, p. 160-164.

Research output: Contribution to journalArticle

Suzuki, K, Aoki, J, Tanizaki, Y, Sakamoto, Y, Takahashi, S, Abe, A, Kimura, H, Kano, T, Suda, S, Nishiyama, Y, Akaji, K, Mihara, B & Kimura, K 2016, 'Characteristics of subcortical infarction due to distal MCA penetrating artery occlusion', Journal of the Neurological Sciences, vol. 368, pp. 160-164. https://doi.org/10.1016/j.jns.2016.07.005
Suzuki, Kentaro ; Aoki, Junya ; Tanizaki, Yoshio ; Sakamoto, Yuki ; Takahashi, Satoshi ; Abe, Arata ; Kimura, Hiroaki ; Kano, Tadashige ; Suda, Satoshi ; Nishiyama, Yasuhiro ; Akaji, Kazunori ; Mihara, Ban ; Kimura, Kazumi. / Characteristics of subcortical infarction due to distal MCA penetrating artery occlusion. In: Journal of the Neurological Sciences. 2016 ; Vol. 368. pp. 160-164.
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abstract = "Objective Isolated deep subcortical infarcts develop as a result of occlusion of the penetrating arteries from the internal carotid artery (ICA) and the proximal (M1) and distal middle cerebral artery (MCA). However, the clinical and neuroimaging characteristics of infarcts due to the occlusion of the distal MCA penetrating artery are unclear. Methods Consecutive patients with ischemic stroke or transient ischemic attack with magnetic resonance imaging (MRI) performed within 2 days of onset were studied retrospectively. Using coronal MRI data, isolated deep subcortical infarcts were classified into two groups: 1) proximal group, described as being longer than they are wide, which were expected to be related to the occlusion of the ICA or M1 penetrating artery; and 2) distal group, described as oblong, which were expected to be associated with the occlusion of penetrating arteries from the distal MCA (M2/M3/M4). Results A total of 653 consecutive acute ischemic stroke patients (proximal group, 50 [7.7{\%}]; distal group, 14 [2.1{\%}]) were enrolled. Baseline clinical characteristics were not different between the 2 groups. Modified Rankin Scale scores were lower in the distal group than in the proximal group 3 months after stroke onset (1.43 ± 0.36 vs. 2.26 ± 1.35, p = 0.023). We measured the lengths of the infarcts in the X and Y directions using axial MRI. The X/Y ratio was larger in the distal group than in the proximal group (1.3 ± 0.6 vs. 0.7 ± 0.2, p ",
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T1 - Characteristics of subcortical infarction due to distal MCA penetrating artery occlusion

AU - Suzuki, Kentaro

AU - Aoki, Junya

AU - Tanizaki, Yoshio

AU - Sakamoto, Yuki

AU - Takahashi, Satoshi

AU - Abe, Arata

AU - Kimura, Hiroaki

AU - Kano, Tadashige

AU - Suda, Satoshi

AU - Nishiyama, Yasuhiro

AU - Akaji, Kazunori

AU - Mihara, Ban

AU - Kimura, Kazumi

PY - 2016/9/15

Y1 - 2016/9/15

N2 - Objective Isolated deep subcortical infarcts develop as a result of occlusion of the penetrating arteries from the internal carotid artery (ICA) and the proximal (M1) and distal middle cerebral artery (MCA). However, the clinical and neuroimaging characteristics of infarcts due to the occlusion of the distal MCA penetrating artery are unclear. Methods Consecutive patients with ischemic stroke or transient ischemic attack with magnetic resonance imaging (MRI) performed within 2 days of onset were studied retrospectively. Using coronal MRI data, isolated deep subcortical infarcts were classified into two groups: 1) proximal group, described as being longer than they are wide, which were expected to be related to the occlusion of the ICA or M1 penetrating artery; and 2) distal group, described as oblong, which were expected to be associated with the occlusion of penetrating arteries from the distal MCA (M2/M3/M4). Results A total of 653 consecutive acute ischemic stroke patients (proximal group, 50 [7.7%]; distal group, 14 [2.1%]) were enrolled. Baseline clinical characteristics were not different between the 2 groups. Modified Rankin Scale scores were lower in the distal group than in the proximal group 3 months after stroke onset (1.43 ± 0.36 vs. 2.26 ± 1.35, p = 0.023). We measured the lengths of the infarcts in the X and Y directions using axial MRI. The X/Y ratio was larger in the distal group than in the proximal group (1.3 ± 0.6 vs. 0.7 ± 0.2, p 

AB - Objective Isolated deep subcortical infarcts develop as a result of occlusion of the penetrating arteries from the internal carotid artery (ICA) and the proximal (M1) and distal middle cerebral artery (MCA). However, the clinical and neuroimaging characteristics of infarcts due to the occlusion of the distal MCA penetrating artery are unclear. Methods Consecutive patients with ischemic stroke or transient ischemic attack with magnetic resonance imaging (MRI) performed within 2 days of onset were studied retrospectively. Using coronal MRI data, isolated deep subcortical infarcts were classified into two groups: 1) proximal group, described as being longer than they are wide, which were expected to be related to the occlusion of the ICA or M1 penetrating artery; and 2) distal group, described as oblong, which were expected to be associated with the occlusion of penetrating arteries from the distal MCA (M2/M3/M4). Results A total of 653 consecutive acute ischemic stroke patients (proximal group, 50 [7.7%]; distal group, 14 [2.1%]) were enrolled. Baseline clinical characteristics were not different between the 2 groups. Modified Rankin Scale scores were lower in the distal group than in the proximal group 3 months after stroke onset (1.43 ± 0.36 vs. 2.26 ± 1.35, p = 0.023). We measured the lengths of the infarcts in the X and Y directions using axial MRI. The X/Y ratio was larger in the distal group than in the proximal group (1.3 ± 0.6 vs. 0.7 ± 0.2, p 

KW - Clinical outcome

KW - Diffusion-weighted imaging

KW - Infarct evolution

KW - Ischemic stroke

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U2 - 10.1016/j.jns.2016.07.005

DO - 10.1016/j.jns.2016.07.005

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JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

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