TY - JOUR
T1 - Characterization of a Neutral Polysaccharide Having Activity on the Reticuloendothelial System from the Rhizome of Curcuma longa
AU - Gonda, Ryoko
AU - Takeda, Kenji
AU - Shimizu, Noriko
AU - Tomoda, Masashi
PY - 1992
Y1 - 1992
N2 - A neutral polysaccharide, named ukonan D, was isolated from the rhizome of Curcuma longa L. It produced a single band on electrophoresis and a single peak on gel chromatography, and its molecular mass was estimated to be 28000. It showed remarkable reticuloendothelial system-potentiating activity in a carbon clearance test. Ukonan D is composed of L-arabinose: D-galactose: D-glucose: D-mannose in the molar ratio of 1:1:12:0.2, in addition to small amounts of peptide moiety. Methylation analysis, carbon-13 nuclear magnetic resonance and enzymic degradation studies indicated that its structural features include mainly both a-l,5-linked L-arabino-/?-3,6-branched D-galactan type and a-4,6-branched D-glucan type structural units. The influence of degradation with a-amylase followed by the elimination of glucan side chains on its immunological activity was discussed.
AB - A neutral polysaccharide, named ukonan D, was isolated from the rhizome of Curcuma longa L. It produced a single band on electrophoresis and a single peak on gel chromatography, and its molecular mass was estimated to be 28000. It showed remarkable reticuloendothelial system-potentiating activity in a carbon clearance test. Ukonan D is composed of L-arabinose: D-galactose: D-glucose: D-mannose in the molar ratio of 1:1:12:0.2, in addition to small amounts of peptide moiety. Methylation analysis, carbon-13 nuclear magnetic resonance and enzymic degradation studies indicated that its structural features include mainly both a-l,5-linked L-arabino-/?-3,6-branched D-galactan type and a-4,6-branched D-glucan type structural units. The influence of degradation with a-amylase followed by the elimination of glucan side chains on its immunological activity was discussed.
KW - Curcuma longa
KW - enzymic degradation
KW - immunological activity
KW - methylation analysis
KW - polysaccharide structure
KW - reticuloendothelial system
KW - rhizome
KW - ukonan D
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U2 - 10.1248/cpb.40.185
DO - 10.1248/cpb.40.185
M3 - Article
C2 - 1576672
AN - SCOPUS:0026592524
SN - 0009-2363
VL - 40
SP - 185
EP - 188
JO - Chemical and Pharmaceutical Bulletin
JF - Chemical and Pharmaceutical Bulletin
IS - 1
ER -