Characterization of a neutral polysaccharide having activity on the reticuloendothelial system from the rhizome of Curcuma longa

Ryoko Gonda, K. Takeda, N. Shimizu, M. Tomoda

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

A neutral polysaccharide, named ukonan D, was isolated from the rhizome of Curcuma longa L. It produced a single band on electrophoresis and a single peak on gel chromatography, and its molecular mass was estimated to be 28000. It showed remarkable reticuloendothelial system-potentiating activity in a carbon clearance test. Ukonan D is composed of L-arabinose: D-galactose: D-glucose: D-mannose in the molar ratio of 1:1:12:0.2, in addition to small amounts of peptide moiety. Methylation analysis, carbon-13 nuclear magnetic resonance and enzymic degradation studies indicated that its structural features include mainly both α-1,5-linked L-arabino-β-3,6-branched D-galactan type and α-4,6-branched D-glucan type structural units. The influence of degradation with α-amylase followed by the elimination of glucan side chains on its immunological activity was discussed.

Original languageEnglish
Pages (from-to)185-188
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume40
Issue number1
Publication statusPublished - 1992

Fingerprint

Curcuma
Mononuclear Phagocyte System
Rhizome
Polysaccharides
Carbon
Degradation
Arabinose
Methylation
Glucans
Molecular mass
Amylases
Mannose
Chromatography
Electrophoresis
Galactose
Gel Chromatography
Magnetic Resonance Spectroscopy
Gels
Nuclear magnetic resonance
Glucose

ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Characterization of a neutral polysaccharide having activity on the reticuloendothelial system from the rhizome of Curcuma longa. / Gonda, Ryoko; Takeda, K.; Shimizu, N.; Tomoda, M.

In: Chemical and Pharmaceutical Bulletin, Vol. 40, No. 1, 1992, p. 185-188.

Research output: Contribution to journalArticle

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