Characterization of a Neutral Polysaccharide Having Activity on the Reticuloendothelial System from the Rhizome of Curcuma longa

Ryoko Gonda, Kenji Takeda, Noriko Shimizu, Masashi Tomoda

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

A neutral polysaccharide, named ukonan D, was isolated from the rhizome of Curcuma longa L. It produced a single band on electrophoresis and a single peak on gel chromatography, and its molecular mass was estimated to be 28000. It showed remarkable reticuloendothelial system-potentiating activity in a carbon clearance test. Ukonan D is composed of L-arabinose: D-galactose: D-glucose: D-mannose in the molar ratio of 1:1:12:0.2, in addition to small amounts of peptide moiety. Methylation analysis, carbon-13 nuclear magnetic resonance and enzymic degradation studies indicated that its structural features include mainly both a-l,5-linked L-arabino-/?-3,6-branched D-galactan type and a-4,6-branched D-glucan type structural units. The influence of degradation with a-amylase followed by the elimination of glucan side chains on its immunological activity was discussed.

Original languageEnglish
Pages (from-to)185-188
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume40
Issue number1
DOIs
Publication statusPublished - 1992

Keywords

  • Curcuma longa
  • enzymic degradation
  • immunological activity
  • methylation analysis
  • polysaccharide structure
  • reticuloendothelial system
  • rhizome
  • ukonan D

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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