Characterization of a Novel Acidic Polysaccharide with Immunological Activities from the Rhizome of Cnidium officinale

Naoko Ohara, Noriko Shimizu, Ryoko Gonda, Masashi Tomoda

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

An acidic polysaccharide, called cnidirhan SIIB, was isolated from the rhizome of Cnidium officinale Makino. It was homogeneous on electrophoresis and gel chromatography, and its molecular mass was estimated to be 7.9 x 104. It was composed of L-arabinose, D-galactose and D-galacturonic acid in the molar ratio of 9:11:3, in addition to a few 0-acetyl groups. Reduction of carboxyl groups, methylation analysis, nuclear magnetic resonance and controlled Smith degradation studies indicated that its structural features are composed primarily of α-L-arabino-β-3,6- and 3,4-branched D-galactan type units. The polysaccharide showed very pronounced reticuloendothelial system-potentiating activity in a carbon clearance test and marked anti-complementary activity.

Original languageEnglish
Pages (from-to)1886-1889
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume42
Issue number9
DOIs
Publication statusPublished - 1994 Jan 1

Keywords

  • Cnidium officinale
  • acidic arabinogalactan
  • cnidirhan SIIB
  • immunological activity
  • polysaccharide structure

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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