Characterization of a novel acidic polysaccharide with immunological activities from the rhizome of Cnidium officinale

N. Ohara, M. Tomoda, Ryoko Gonda, R. Gonda

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

An acidic polysaccharide, called cnidirhan SIIB, was isolated from the rhizome of Cnidium officinale Makino. It was homogeneous on electrophoresis and gel chromatography, and its molecular mass was estimated to be 7.9 x 104. It was composed of L-arabinose, D-galactose and D-galacturonic acid in the molar ratio of 9:11:3, in addition to a few O-acetyl groups. Reduction of carboxyl groups, methylation analysis, nuclear magnetic resonance and controlled Smith degradation studies indicated that its structural features are composed primarily of α-L-arabino-β-3,6- and 3,4-branched D-galactan type units. The polysaccharide showed very pronounced reticuloendothelial system-potentiating activity in a carbon clearance test and marked anti-complementary activity.

Original languageEnglish
Pages (from-to)1886-1889
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume42
Issue number9
Publication statusPublished - 1994

Fingerprint

Cnidium
Rhizome
Polysaccharides
Mononuclear Phagocyte System
Arabinose
Methylation
Molecular mass
Chromatography
Electrophoresis
Galactose
Gel Chromatography
Magnetic Resonance Spectroscopy
Carbon
Gels
Nuclear magnetic resonance
Degradation

Keywords

  • acidic arabinogalactan
  • cnidirhan SIIB
  • Cnidium officinale
  • immunological activity
  • polysaccharide structure

ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Characterization of a novel acidic polysaccharide with immunological activities from the rhizome of Cnidium officinale. / Ohara, N.; Tomoda, M.; Gonda, Ryoko; Gonda, R.

In: Chemical and Pharmaceutical Bulletin, Vol. 42, No. 9, 1994, p. 1886-1889.

Research output: Contribution to journalArticle

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