Characterization of a Polysaccharide Having Activity on the Reticuloendothelial System from the Stolon of Glycyrrhiza glabra var: Glanduhfera

Noriko Shimizu, Masashi Tomoda, Makiko Satoh, Ryoko Gonda, Naoko Ohara

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

An acidic polysaccharide, named glycyrrhizan GA, was isolated from the stolon of Glycyrrhiza glabra L. var. glandulifera reg.etherd. It produced a single band on electrophoresis and a single peak on gel chromatography, and its molecular mass was estimated to be 85000. Glycyrrhizan GA is composed of L-arabinose: D-galactose: L-rhamnose: D-galacturonic acid:D-glucuronic acid in the molar ratio of 22:10:1:2:1, in addition to small amounts of 0-acetyl groups. Part of the hexuronic acid residues exist as methyl esters. Methylation analysis, carbon-13 nuclear magnetic resonance and periodate oxidation studies indicated that its structural features include mainly a-arabino-/l-3,6-galactan type structural units. Glycyrrhizan GA showed remarkable reticuloendothelial system-potentiating activity in a carbon clearance test.

Original languageEnglish
Pages (from-to)2082-2086
Number of pages5
JournalChemical and Pharmaceutical Bulletin
Volume39
Issue number8
DOIs
Publication statusPublished - 1991 Jan 1

Keywords

  • Keywords Glyeyrrhiza glabra var. glandulifera
  • acidic arabinogalactan
  • glycyrrhizan GA
  • immunological activity
  • licorice
  • polysaccharide
  • reticuloendothelial system
  • stolon
  • structural features

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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