Characterization of RNA aptamers against SRP19 protein having sequences different from SRP RNA.

Yuki Haraguchi, Kanako Kuwasako, Yutaka Muto, Yoshitaka Bessho, Madoka Nishimoto, Shigeyuki Yokoyama, Akio Kanai, Gota Kawai, Taiichi Sakamoto

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Abstract

SELEX is a conventional method to obtain high affinity nucleic acids to target molecules. In this study, high affinity RNA molecules against SRP19 protein were selected by using a randomized library. The primary and predicted secondary structures of the aptamers are different from those of S-domain RNA which is the natural target of SRP19 protein. Comparison of structural features between S-domain RNA and aptamers might enhance our understanding on RNA-protein interaction.

Original languageEnglish
Pages (from-to)265-266
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number53
Publication statusPublished - 2009

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Haraguchi, Y., Kuwasako, K., Muto, Y., Bessho, Y., Nishimoto, M., Yokoyama, S., Kanai, A., Kawai, G., & Sakamoto, T. (2009). Characterization of RNA aptamers against SRP19 protein having sequences different from SRP RNA. Nucleic acids symposium series (2004), (53), 265-266.