Characterization of two Polysaccharides Having Activity on the Reticuloendothelial System from the Root of Glycyrrhiza uralensis

Masashi Tomoda, Noriko Shimizu, Mieko Kanari, Ryōko Gonda, Sumiko Arai, Yūko Okuda

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Two polysaccharides, called glycyrrhizans UA and UB, were isolated from the root of Glycyrrhiza uralensis Fischer. They were homogeneous on electrophoresis and gel chromatography, and showed reticuloendothelial system-potentiating activity in a carbon clearance test. Glycyrrhizan UA is composed of L-arabinose: D-galactose: L-rhamnose: D-galacturonic acid in the molar ratio of 20:14:1:3, and glycyrrhizan UB is composed of L-arabinose: D-galactose: D-glucose: L-rhamnose: D-galacturonic acid in the molar ratio of 12:10:1:10:20, in addition to small amounts of O-acetyl groups and peptide moiety, respectively. About 10% (glycyrrhizan UA) and 35% (glycyrrhizan UB) of the D-galacturonic acid residues exist as the methyl esters. Methylation analysis, carbon-13 nuclear magnetic resonance and periodate oxidation studies indicated their structural features.

Original languageEnglish
Pages (from-to)1667-1671
Number of pages5
JournalChemical and Pharmaceutical Bulletin
Volume38
Issue number6
DOIs
Publication statusPublished - 1990

Keywords

  • Glycyrrhiza uralensis
  • acidic arabinogalactan
  • glycyrrhizan UA
  • glycyrrhizan UB
  • immunological activity
  • licorice
  • polysaccharide structure
  • reticuloendothelial system
  • root

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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