Chemical approach for target-selective degradation of oligosaccharides using photoactivatable organic molecules

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Molecular design, chemical synthesis, and biological evaluation of several organic molecules, which can target-selectively photodegrade oligosaccharides by irradiation with a specific wavelength of light under mild conditions without any additives, are introduced. These novel class of photochemical agents promise bright prospects for finding not only molecular-targeted bioprobes for understanding of the structure-activity relationships of oligosaccharides but also novel therapeutic drugs targeting biologically important oligosaccharides.

Original languageEnglish
Pages (from-to)475-482
Number of pages8
JournalGlycoconjugate Journal
Volume32
Issue number7
DOIs
Publication statusPublished - 2015 Apr 28

Fingerprint

Oligosaccharides
Degradation
Molecules
Biosensing Techniques
Drug Delivery Systems
Structure-Activity Relationship
Irradiation
Light
Wavelength
Therapeutics

Keywords

  • Anthracene
  • Anthraquinone
  • Boronic acid
  • Kemp's acid
  • Lectin
  • Photodegradation

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

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title = "Chemical approach for target-selective degradation of oligosaccharides using photoactivatable organic molecules",
abstract = "Molecular design, chemical synthesis, and biological evaluation of several organic molecules, which can target-selectively photodegrade oligosaccharides by irradiation with a specific wavelength of light under mild conditions without any additives, are introduced. These novel class of photochemical agents promise bright prospects for finding not only molecular-targeted bioprobes for understanding of the structure-activity relationships of oligosaccharides but also novel therapeutic drugs targeting biologically important oligosaccharides.",
keywords = "Anthracene, Anthraquinone, Boronic acid, Kemp's acid, Lectin, Photodegradation",
author = "Kazunobu Toshima and Daisuke Takahashi",
year = "2015",
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doi = "10.1007/s10719-015-9591-9",
language = "English",
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pages = "475--482",
journal = "Glycoconjugate Journal",
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AU - Takahashi, Daisuke

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N2 - Molecular design, chemical synthesis, and biological evaluation of several organic molecules, which can target-selectively photodegrade oligosaccharides by irradiation with a specific wavelength of light under mild conditions without any additives, are introduced. These novel class of photochemical agents promise bright prospects for finding not only molecular-targeted bioprobes for understanding of the structure-activity relationships of oligosaccharides but also novel therapeutic drugs targeting biologically important oligosaccharides.

AB - Molecular design, chemical synthesis, and biological evaluation of several organic molecules, which can target-selectively photodegrade oligosaccharides by irradiation with a specific wavelength of light under mild conditions without any additives, are introduced. These novel class of photochemical agents promise bright prospects for finding not only molecular-targeted bioprobes for understanding of the structure-activity relationships of oligosaccharides but also novel therapeutic drugs targeting biologically important oligosaccharides.

KW - Anthracene

KW - Anthraquinone

KW - Boronic acid

KW - Kemp's acid

KW - Lectin

KW - Photodegradation

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