Abstract
Proteins and carbohydrates play crucial roles in a wide range of biological processes, including serious diseases. The development of novel and innovative methods for selective control of specific proteins and carbohydrates functions has attracted much attention in the field of chemical biology. In this account article, the development of novel chemical tools, which can degrade target proteins and carbohydrates by irradiation with a specific wavelength of light under mild conditions without any additives, is introduced. This novel class of photochemical agents promise bright prospects for finding not only molecular-targeted bioprobes for understanding of the structure-activity relationships of proteins and carbohydrates but also novel therapeutic drugs targeting proteins and carbohydrates.
| Original language | English |
|---|---|
| Pages (from-to) | 834-854 |
| Number of pages | 21 |
| Journal | Molecular BioSystems |
| Volume | 9 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2013 May |
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ASJC Scopus subject areas
- Biotechnology
- Molecular Biology
Cite this
Chemical biology based on target-selective degradation of proteins and carbohydrates using light-activatable organic molecules. / Toshima, Kazunobu.
In: Molecular BioSystems, Vol. 9, No. 5, 05.2013, p. 834-854.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chemical biology based on target-selective degradation of proteins and carbohydrates using light-activatable organic molecules
AU - Toshima, Kazunobu
PY - 2013/5
Y1 - 2013/5
N2 - Proteins and carbohydrates play crucial roles in a wide range of biological processes, including serious diseases. The development of novel and innovative methods for selective control of specific proteins and carbohydrates functions has attracted much attention in the field of chemical biology. In this account article, the development of novel chemical tools, which can degrade target proteins and carbohydrates by irradiation with a specific wavelength of light under mild conditions without any additives, is introduced. This novel class of photochemical agents promise bright prospects for finding not only molecular-targeted bioprobes for understanding of the structure-activity relationships of proteins and carbohydrates but also novel therapeutic drugs targeting proteins and carbohydrates.
AB - Proteins and carbohydrates play crucial roles in a wide range of biological processes, including serious diseases. The development of novel and innovative methods for selective control of specific proteins and carbohydrates functions has attracted much attention in the field of chemical biology. In this account article, the development of novel chemical tools, which can degrade target proteins and carbohydrates by irradiation with a specific wavelength of light under mild conditions without any additives, is introduced. This novel class of photochemical agents promise bright prospects for finding not only molecular-targeted bioprobes for understanding of the structure-activity relationships of proteins and carbohydrates but also novel therapeutic drugs targeting proteins and carbohydrates.
UR - http://www.scopus.com/inward/record.url?scp=84875835416&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875835416&partnerID=8YFLogxK
U2 - 10.1039/c2mb25416f
DO - 10.1039/c2mb25416f
M3 - Article
C2 - 23247895
AN - SCOPUS:84875835416
VL - 9
SP - 834
EP - 854
JO - Molecular BioSystems
JF - Molecular BioSystems
SN - 1742-206X
IS - 5
ER -