TY - JOUR
T1 - Chemical confirmation of the structure of a mutagenic aminophenylnorharman, 9-(4'-aminophenyl)-9H-pyrido[3,4-b]indole
T2 - An authentic synthesis of 9-(4'nitrophenyl)-9H- pyrido[3,4-b]indole as its relay compound
AU - Murakami, Yasuoki
AU - Imai, Nobuyuki
AU - Miura, Tsuyoshi
AU - Sugimura, Takashi
AU - Wakabayashi, Keiji
AU - Totsuka, Yukari
AU - Hada, Noriyasu
AU - Yokoyama, Yuusaku
AU - Suzuki, Hideharu
AU - Mitsunaga, Katsuyoshi
PY - 2010/1/1
Y1 - 2010/1/1
N2 - 9-(4'-Aminophenyl)-9H-pyrido[3,4-b]indole 2 is a mutagenic compound produced by non-mutagenic norharman 1 and aniline in the presence of S9 mix. 9-(4'-Nitrophenyl)-9H-pyrido[3,4-b]indole 4, the relay compound for synthesis of 2, was synthesized starting from ethyl indole-2-aldehyde 12 via initial N-(4-nitro)phenylation of the indole nucleus, elongation of the 2-aldehyde substituent, and then construction of the pyridine nucleus in order to ensure the nitrogen substitution in 2.
AB - 9-(4'-Aminophenyl)-9H-pyrido[3,4-b]indole 2 is a mutagenic compound produced by non-mutagenic norharman 1 and aniline in the presence of S9 mix. 9-(4'-Nitrophenyl)-9H-pyrido[3,4-b]indole 4, the relay compound for synthesis of 2, was synthesized starting from ethyl indole-2-aldehyde 12 via initial N-(4-nitro)phenylation of the indole nucleus, elongation of the 2-aldehyde substituent, and then construction of the pyridine nucleus in order to ensure the nitrogen substitution in 2.
KW - 9H-Pyrido[3,4-b]indole
KW - Cyclization
KW - Indole Nucleus
KW - Norharman
KW - Synthesis
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U2 - 10.3987/COM-09-S(S)45
DO - 10.3987/COM-09-S(S)45
M3 - Article
AN - SCOPUS:76949092529
SN - 0385-5414
VL - 80
SP - 455
EP - 462
JO - Heterocycles
JF - Heterocycles
IS - 1
ER -