Chemical decontamination of iPS cell-derived neural cell mixtures

Di Mao, Xie Khim Watson Chung, Tomoko Andoh-Noda, Ying Qin, Shin Ichi Sato, Yasushi Takemoto, Wado Akamatsu, Hideyuki Okano, Motonari Uesugi

Research output: Contribution to journalArticle

Abstract

This report describes the design and evaluation of phosphorylated 7-ethyl-10-hydroxycamptothecin (SN38-P), which selectively eliminates tumor-forming proliferative stem cells, including human induced pluripotent stem cells (hiPSCs) and neural stem cells, from iPSC-derived neural cell mixtures. Results of the present study demonstrate that simple phosphorylation of an anticancer drug can provide a safe, cost-effective, and chemically-defined tool for decontaminating hiPSC-derived neuron.

Original languageEnglish
Pages (from-to)1355-1358
Number of pages4
JournalChemical Communications
Volume54
Issue number11
DOIs
Publication statusPublished - 2018 Jan 1

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Decontamination
Stem cells
irinotecan
Phosphorylation
Neurons
Tumors
Pharmaceutical Preparations
Costs

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Mao, D., Chung, X. K. W., Andoh-Noda, T., Qin, Y., Sato, S. I., Takemoto, Y., ... Uesugi, M. (2018). Chemical decontamination of iPS cell-derived neural cell mixtures. Chemical Communications, 54(11), 1355-1358. https://doi.org/10.1039/c7cc08686e

Chemical decontamination of iPS cell-derived neural cell mixtures. / Mao, Di; Chung, Xie Khim Watson; Andoh-Noda, Tomoko; Qin, Ying; Sato, Shin Ichi; Takemoto, Yasushi; Akamatsu, Wado; Okano, Hideyuki; Uesugi, Motonari.

In: Chemical Communications, Vol. 54, No. 11, 01.01.2018, p. 1355-1358.

Research output: Contribution to journalArticle

Mao, D, Chung, XKW, Andoh-Noda, T, Qin, Y, Sato, SI, Takemoto, Y, Akamatsu, W, Okano, H & Uesugi, M 2018, 'Chemical decontamination of iPS cell-derived neural cell mixtures', Chemical Communications, vol. 54, no. 11, pp. 1355-1358. https://doi.org/10.1039/c7cc08686e
Mao D, Chung XKW, Andoh-Noda T, Qin Y, Sato SI, Takemoto Y et al. Chemical decontamination of iPS cell-derived neural cell mixtures. Chemical Communications. 2018 Jan 1;54(11):1355-1358. https://doi.org/10.1039/c7cc08686e
Mao, Di ; Chung, Xie Khim Watson ; Andoh-Noda, Tomoko ; Qin, Ying ; Sato, Shin Ichi ; Takemoto, Yasushi ; Akamatsu, Wado ; Okano, Hideyuki ; Uesugi, Motonari. / Chemical decontamination of iPS cell-derived neural cell mixtures. In: Chemical Communications. 2018 ; Vol. 54, No. 11. pp. 1355-1358.
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