Chemical decontamination of iPS cell-derived neural cell mixtures

Di Mao, Xie Khim Watson Chung, Tomoko Andoh-Noda, Ying Qin, Shin Ichi Sato, Yasushi Takemoto, Wado Akamatsu, Hideyuki Okano, Motonari Uesugi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

This report describes the design and evaluation of phosphorylated 7-ethyl-10-hydroxycamptothecin (SN38-P), which selectively eliminates tumor-forming proliferative stem cells, including human induced pluripotent stem cells (hiPSCs) and neural stem cells, from iPSC-derived neural cell mixtures. Results of the present study demonstrate that simple phosphorylation of an anticancer drug can provide a safe, cost-effective, and chemically-defined tool for decontaminating hiPSC-derived neuron.

Original languageEnglish
Pages (from-to)1355-1358
Number of pages4
JournalChemical Communications
Volume54
Issue number11
DOIs
Publication statusPublished - 2018 Jan 1

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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  • Cite this

    Mao, D., Chung, X. K. W., Andoh-Noda, T., Qin, Y., Sato, S. I., Takemoto, Y., Akamatsu, W., Okano, H., & Uesugi, M. (2018). Chemical decontamination of iPS cell-derived neural cell mixtures. Chemical Communications, 54(11), 1355-1358. https://doi.org/10.1039/c7cc08686e