Chemical glycan conjugation controls the biodistribution and kinetics of proteins in live animals

Akihiro Ogura, A. Kurbangalieva, K. Tanaka

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The biodistributions and in vivo kinetics of chemically prepared neoglycoproteins have been examined previously and are reviewed here. A variety of mono- and oligosaccharides may be conjugated onto a protein surface using chemical methods. The kinetics and organ-specific accumulation profiles of these glycoconjugates, introduced through intravenous injection, have been analyzed using conventional dissection studies as well as noninvasive methods, such as SPECT, PET, or fluorescence imaging. These studies have revealed glycan-dependent protein distribution kinetics that may be useful for pharmacological and diagnostic applications.

Original languageEnglish
Pages (from-to)1072-1077
Number of pages6
JournalMini-Reviews in Medicinal Chemistry
Volume14
Issue number13
Publication statusPublished - 2014 Oct 1
Externally publishedYes

Fingerprint

Polysaccharides
Proteins
Glycoconjugates
Monosaccharides
Optical Imaging
Single-Photon Emission-Computed Tomography
Oligosaccharides
Intravenous Injections
Dissection
Glycoproteins
Membrane Proteins
Pharmacology

Keywords

  • Albumin
  • Bioconjugation
  • Biodistribution
  • Chemical reaction
  • In vivo imaging
  • N-glycans
  • Neoglycoprotein
  • Tumor targeting

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Medicine(all)

Cite this

Chemical glycan conjugation controls the biodistribution and kinetics of proteins in live animals. / Ogura, Akihiro; Kurbangalieva, A.; Tanaka, K.

In: Mini-Reviews in Medicinal Chemistry, Vol. 14, No. 13, 01.10.2014, p. 1072-1077.

Research output: Contribution to journalArticle

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