Chemical methods for degradation of target proteins using designed light-activatable organic molecules

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Molecular design, chemical synthesis, and biological evaluation of several designed organic molecules, which target-selectively degrade proteins upon photo-irradiation, are introduced. The designed molecules for protein photo-degradation include 2-phenylquinoline-steroid hormone hybrids and porphyrin derivatives, both of which selectively photo-degrade estrogen receptor-α, and fullerene-sugar and -sulfonic acid hybrids, which selectively photo-degrade HIV-1 protease and amyloid β, respectively. The information will provide a novel and effective way to control specific functions of proteins, and contribute to the molecular design of novel protein photo-degrading agents, which should find wide application in chemistry, biology, and medicine. This journal is

Original languageEnglish
Pages (from-to)7659-7671
Number of pages13
JournalChemical Communications
Volume48
Issue number62
DOIs
Publication statusPublished - 2012 Aug 11

Fingerprint

Proteins
Degradation
Molecules
Steroid hormones
Fullerenes
Sulfonic Acids
Porphyrins
Photodegradation
Amyloid
Sugars
Estrogen Receptors
Medicine
Irradiation
Derivatives
Acids
Human immunodeficiency virus 1 p16 protease
2-phenylquinoline
Peptide Hydrolases
Estrogens

ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)

Cite this

Chemical methods for degradation of target proteins using designed light-activatable organic molecules. / Tanimoto, Shuho; Takahashi, Daisuke; Toshima, Kazunobu.

In: Chemical Communications, Vol. 48, No. 62, 11.08.2012, p. 7659-7671.

Research output: Contribution to journalArticle

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