Chemistry and biology for the small molecules targeting characteristics of cancer cells

Research output: Contribution to journalReview article

Abstract

Despite the marked progress of cancer research, cancer is the predominant cause of death in Japan, and therefore development of effective therapeutic drugs is expected. Chemical biology is a research field utilizing small molecules to investigate biological phenomena. One of the most important aims of chemical biology is to find the small molecules, and natural products are ideal screening sources due to their structural diversity. Therefore, natural product screening based on the progress of chemical biology prompted us to find small molecules targeting cancer characteristics. Another contribution of chemical biology is to facilitate the target identification of small molecule. Therefore, among a variety of methods to uncover protein function, chemical biology is a remarkable approach in which small molecules are used as probes to elucidate protein functions related to cancer development.

Original languageEnglish
Pages (from-to)10-19
Number of pages10
JournalBioscience, Biotechnology and Biochemistry
Volume83
Issue number1
DOIs
Publication statusPublished - 2019 Jan 1

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Cells
Molecules
Neoplasms
Biological Products
Screening
Biological Phenomena
Research
Cause of Death
Japan
Proteins
Pharmaceutical Preparations
Therapeutics

Keywords

  • Androgen receptor antagonist
  • Apoptosis
  • Autophagy
  • Cell migration
  • Natural product
  • Oncogenes

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

Cite this

Chemistry and biology for the small molecules targeting characteristics of cancer cells. / Imoto, Masaya.

In: Bioscience, Biotechnology and Biochemistry, Vol. 83, No. 1, 01.01.2019, p. 10-19.

Research output: Contribution to journalReview article

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