Chemistry and biology of the compounds that modulate cell migration

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Abstract

Cell migration is a fundamental step for embryonic development, wound repair, immune responses, and tumor cell invasion and metastasis. Extensive studies have attempted to reveal the molecular mechanisms behind cell migration; however, they remain largely unclear. Bioactive compounds that modulate cell migration show promise as not only extremely powerful tools for studying the mechanisms behind cell migration but also as drug seeds for chemotherapy against tumor metastasis. Therefore, we have screened cell migration inhibitors and analyzed their mechanisms for the inhibition of cell migration. In this mini-review, we introduce our chemical and biological studies of three cell migration inhibitors: moverastin, UTKO1, and BU-4664L.

Original languageEnglish
Pages (from-to)213-219
Number of pages7
JournalJournal of Industrial Microbiology and Biotechnology
Volume43
Issue number2-3
DOIs
Publication statusPublished - 2016 Mar 1

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Keywords

  • 14-3-3
  • 5-Lipoxygenase
  • Cell migration
  • Cysteinyl leukotriene receptor 1
  • Farnesyltransferase
  • Lamellipodia
  • Rac1

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology

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