Chemistry Based Approach for Degradation of Target-Oligosaccharides Using Photo-Activatable Organic Small Molecules

Daisuke Takahashi, Kazunobu Toshima

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Molecular design, chemical synthesis, and biological evaluation of several organic small molecules, which can target-selectively photodegrade oligosaccharides by irradiation with a specific wavelength of light under mild conditions without any additives, are introduced. These novel class of photochemical agents promise bright prospects for finding not only molecular-targeted bioprobes for understanding of the structure-activity relationships of oligosaccharides but also novel therapeutic drugs targeting biologically active oligosaccharides.

Original languageEnglish
Pages (from-to)258-276
Number of pages19
JournalTrends in Glycoscience and Glycotechnology
Volume24
Issue number140
DOIs
Publication statusPublished - 2012 Jan 1

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Keywords

  • anthraquinone
  • boronic acid
  • fullerene
  • hybrid molecule
  • photodegradation

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

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