Chemoradiotherapy for advanced gastric cancer

Tsunehiro Takahashi, Yoshiro Saikawa, Kazumasa Fukuda, Norihito Wada, Hirofumi Kawakubo, Hiroya Takeuchi, Junichi Fukada, Osamu Kawaguchi, Hiromasa Takaishi, Naoyuki Shigematsu, Yuko Kitagawa

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In the US and Europe, chemoradiotherapy has become a standard treatment not only for head and neck cancer, esophageal cancer, pancreatic cancer, and rectal cancer, but also for gastric cancer. In particular, chemoradiotherapy has been established as an adjuvant therapy. In Japan, it has not been established as a standard treatment. Its indications are limited, and it is often performed as palliative care. Disadvantages of radiation therapy for gastric cancer include the difficulty of establishing the area to irradiate due to peristaltic movement, risk of perforation and ulceration from high-dose radiation, and ineffectiveness against adenocarcinoma with low radiosensitivity. In recent years, technological advancement of radiation therapy has enabled pinpoint accuracy in the treatment of primary gastric lesions and regional lymph nodes. There has been much anticipation that chemoradiotherapy will become a part of multidisciplinary treatment for advanced cancer. This report describes the current state of chemoradiotherapy for gastric cancer in Japan and overseas, and outlines our approach to locally advanced gastric cancer.

Original languageEnglish
Pages (from-to)2464-2468
Number of pages5
JournalJapanese Journal of Cancer and Chemotherapy
Volume39
Issue number13
Publication statusPublished - 2012 Dec

Keywords

  • Chemoradiotherapy
  • Local advanced gastric cancer
  • Preoperative chemotherapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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