Chemoradiotherapy is effective for primary esophageal adenosquamous cell carcinoma but ineffective for the metastatic adenocarcinoma component

Yasutoshi Nozaki; Tsutomu Nishida; Yumiko Hori; Shinichiro Shinzaki; Motohiko Kato; Takayuki Yakushijin; Hideki Iijima; Masahiko Tsujii; Eiichi Morii; Tetsuo Takehara

Chemoradiotherapy is effective for primary esophageal adenosquamous cell carcinoma but ineffective for the metastatic adenocarcinoma component

Yasutoshi Nozaki, Tsutomu Nishida, Yumiko Hori, Shinichiro Shinzaki, Motohiko Kato, Takayuki Yakushijin, Hideki Iijima, Masahiko Tsujii, Eiichi Morii, Tetsuo Takehara

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

A 62-year-old man was referred to our hospital with dysphagia. Blood examination revealed significantly elevated serum CA19-9 levels but normal CEA and SCC levels. Imaging uncovered thoracic esophageal cancer with lung and bone metastasis, and subsequent endoscopic biopsy specimens of the primary esophageal tumor showed poorly differentiated squamous cell carcinoma. The patient underwent palliative chemoradiotherapy, but died due to progression of multiple metastases and increasing serum CA19-9 levels. Autopsy revealed adenocarcinoma in multiple metastatic foci, although the squamous component had disappeared in the primary and metastatic lesions. Therefore, we concluded that the adenocarcinoma component of adenosquamous cell carcinoma was refractory to chemoradiotherapy.

Original language	English
Pages (from-to)	278-286
Number of pages	9
Journal	Journal of Japanese Society of Gastroenterology
Volume	112
Issue number	2
Publication status	Published - 2015 Feb 1
Externally published	Yes

ASJC Scopus subject areas

Gastroenterology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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abstract = "A 62-year-old man was referred to our hospital with dysphagia. Blood examination revealed significantly elevated serum CA19-9 levels but normal CEA and SCC levels. Imaging uncovered thoracic esophageal cancer with lung and bone metastasis, and subsequent endoscopic biopsy specimens of the primary esophageal tumor showed poorly differentiated squamous cell carcinoma. The patient underwent palliative chemoradiotherapy, but died due to progression of multiple metastases and increasing serum CA19-9 levels. Autopsy revealed adenocarcinoma in multiple metastatic foci, although the squamous component had disappeared in the primary and metastatic lesions. Therefore, we concluded that the adenocarcinoma component of adenosquamous cell carcinoma was refractory to chemoradiotherapy.",

author = "Yasutoshi Nozaki and Tsutomu Nishida and Yumiko Hori and Shinichiro Shinzaki and Motohiko Kato and Takayuki Yakushijin and Hideki Iijima and Masahiko Tsujii and Eiichi Morii and Tetsuo Takehara",

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T1 - Chemoradiotherapy is effective for primary esophageal adenosquamous cell carcinoma but ineffective for the metastatic adenocarcinoma component

AU - Nozaki, Yasutoshi

AU - Nishida, Tsutomu

AU - Hori, Yumiko

AU - Shinzaki, Shinichiro

AU - Kato, Motohiko

AU - Yakushijin, Takayuki

AU - Iijima, Hideki

AU - Tsujii, Masahiko

AU - Morii, Eiichi

AU - Takehara, Tetsuo

PY - 2015/2/1

Y1 - 2015/2/1

N2 - A 62-year-old man was referred to our hospital with dysphagia. Blood examination revealed significantly elevated serum CA19-9 levels but normal CEA and SCC levels. Imaging uncovered thoracic esophageal cancer with lung and bone metastasis, and subsequent endoscopic biopsy specimens of the primary esophageal tumor showed poorly differentiated squamous cell carcinoma. The patient underwent palliative chemoradiotherapy, but died due to progression of multiple metastases and increasing serum CA19-9 levels. Autopsy revealed adenocarcinoma in multiple metastatic foci, although the squamous component had disappeared in the primary and metastatic lesions. Therefore, we concluded that the adenocarcinoma component of adenosquamous cell carcinoma was refractory to chemoradiotherapy.

AB - A 62-year-old man was referred to our hospital with dysphagia. Blood examination revealed significantly elevated serum CA19-9 levels but normal CEA and SCC levels. Imaging uncovered thoracic esophageal cancer with lung and bone metastasis, and subsequent endoscopic biopsy specimens of the primary esophageal tumor showed poorly differentiated squamous cell carcinoma. The patient underwent palliative chemoradiotherapy, but died due to progression of multiple metastases and increasing serum CA19-9 levels. Autopsy revealed adenocarcinoma in multiple metastatic foci, although the squamous component had disappeared in the primary and metastatic lesions. Therefore, we concluded that the adenocarcinoma component of adenosquamous cell carcinoma was refractory to chemoradiotherapy.

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Chemoradiotherapy is effective for primary esophageal adenosquamous cell carcinoma but ineffective for the metastatic adenocarcinoma component

Abstract

ASJC Scopus subject areas

UN SDGs

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