Chemosensitivity-related genes of breast cancer detected by DNA microarray

Tadashi Ikeda, Hiromitsu Jinno, Masatoshi Shirane

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: The feasibility of a preoperative docetaxel/5′-deoxy-5- fluorouridine (5′-DFUR) regimen for breast cancer patients was examined and the genes related to the response to it was investigated. Patients and Methods: Women with advanced breast cancer were treated with docetaxel (60 mg/m2, day 1) and 5′-DFUR (800 mg/day, on days 1-14) q3 weeks by 4 cycles. Microarray analysis was carried out using preoperative core biopsy samples. Based on the mRNA expression levels, genes related to clinical and pathological responses were selected. Results: The docetaxel/5′-DFUR regimen showed a 86% clinical response rate including 42% complete response, one pathological complete response and one ductal carcinoma in situ component. In microarray analysis, we identified 6 genes, including IGF-1, and derived a predictive formula with 67% accuracy. In addition, χ2 analysis revealed a tendency for good response in ER-negative and Her2/neu-positive cases. Conclusion: Microarray analysis enabled us to predict the pathological response to docetaxel/5′-DFUR chemotherapy.

Original languageEnglish
Pages (from-to)2649-2655
Number of pages7
JournalAnticancer research
Volume27
Issue number4 C
Publication statusPublished - 2007 Jul 1

Keywords

  • 5′-deoxy-5-fluorouridine
  • Docetaxel
  • Microarray
  • Prediction
  • Support vector machine

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Ikeda, T., Jinno, H., & Shirane, M. (2007). Chemosensitivity-related genes of breast cancer detected by DNA microarray. Anticancer research, 27(4 C), 2649-2655.