TY - JOUR
T1 - Chemotherapy for head and neck cancer
T2 - Current status and problems in japan
AU - Tomita, Toshiki
AU - Imanishi, Yorihisa
AU - Ozawa, Hiroyuki
AU - Fujii, Ryoichi
AU - Shigetomi, Seiji
AU - Habu, Noboru
AU - Otsuka, Kuninori
AU - Ogawa, Kaoru
AU - Fukada, Junichi
AU - Shigematsu, Naoyuki
AU - Kogashiwa, Yasunao
AU - Yamauchi, Kohichi
AU - Kohno, Naoyuki
PY - 2010
Y1 - 2010
N2 - A meta-analysis showed that chemoradiotherapy (CCRT) improved survival in patients with advanced head and neck squamous cell carcinoma (HNSCC). CCRT has become widely used in treating such patients. The purpose of CCRT in the treatment of resectable HNSCC is to improve survival while preserving organs and functions, and so CCRT is a potential alternative to surgery. However, problems regarding CCRT were revealed such as severe dysphasia and difficulty of salvage surgery. Recently, induction chemotherapy has attracted attention again, the purpose of which is to predict the response of subsequent CCRT or to improve outcomes. Moreover, chemotherapy is concurrently used with postoperative radiotherapy or definitively used for recurrent or metastatic HNSCC. In this article, we review the current state of chemotherapy for HNSCC and consider the problems in Japan.
AB - A meta-analysis showed that chemoradiotherapy (CCRT) improved survival in patients with advanced head and neck squamous cell carcinoma (HNSCC). CCRT has become widely used in treating such patients. The purpose of CCRT in the treatment of resectable HNSCC is to improve survival while preserving organs and functions, and so CCRT is a potential alternative to surgery. However, problems regarding CCRT were revealed such as severe dysphasia and difficulty of salvage surgery. Recently, induction chemotherapy has attracted attention again, the purpose of which is to predict the response of subsequent CCRT or to improve outcomes. Moreover, chemotherapy is concurrently used with postoperative radiotherapy or definitively used for recurrent or metastatic HNSCC. In this article, we review the current state of chemotherapy for HNSCC and consider the problems in Japan.
KW - Chemoradiotherapy
KW - Chemotherapy
KW - HNSCC
KW - Head and neck cancer
KW - Induction chemotherapy
KW - Multidisciplinary approach
UR - http://www.scopus.com/inward/record.url?scp=85009592635&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85009592635&partnerID=8YFLogxK
U2 - 10.5981/jjhnc.36.273
DO - 10.5981/jjhnc.36.273
M3 - Article
AN - SCOPUS:85009592635
VL - 36
SP - 273
EP - 277
JO - Japanese Journal of Head and Neck Cancer
JF - Japanese Journal of Head and Neck Cancer
SN - 1349-5747
IS - 3
ER -
