Chemotherapy-induced sclerosing cholangitis as a rare indication for resection: Report of a case

Yutaro Kato, Kentaro Matsubara, Yoshinobu Akiyama, Hiroaki Hattori, Akira Hirata, Fumio Suzuki, Hitoshi Ohtaka, Ayu Kato, Yoshiaki Sugiura, Masaki Kitajima

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Bile duct stricture due to chemotherapy-induced sclerosing cholangitis (CISC) is a potentially fatal complication of hepatic arterial infusion chemotherapy (HAIC). It is managed primarily with medical treatment and biliary stenting. We report a rare case of a CISC-related biliary stricture requiring resection. The patient had been receiving adjuvant HAIC for 11 months after a curative liver resection for hepatocellular carcinoma, when clinically overt cholangitis developed. Radiologic and biopsy findings suggested a CISC-related biliary stricture limited to the common hepatic duct. We discontinued HAIC and started corticosteroid treatment, which finally became ineffective. Endoscopic biliary stenting was impossible because of her severe biliary sclerosis, necessitating resection of the stricture, which was confirmed histologically to be secondary sclerosing cholangitis. The patient has shown no signs of recurrent cholangitis for 12 postoperative months since her operation. Thus, resection could be a treatment option for a CISC-related biliary stricture in selected patients.

Original languageEnglish
Pages (from-to)905-908
Number of pages4
JournalSurgery Today
Volume39
Issue number10
DOIs
Publication statusPublished - 2009 Oct
Externally publishedYes

Fingerprint

Sclerosing Cholangitis
Drug Therapy
Pathologic Constriction
Cholangitis
Liver
Common Hepatic Duct
Sclerosis
Bile Ducts
Hepatocellular Carcinoma
Adrenal Cortex Hormones
Therapeutics
Biopsy

Keywords

  • Bile duct
  • Hepatic arterial infusion chemotherapy
  • Resection
  • Sclerosing cholangitis
  • Stricture

ASJC Scopus subject areas

  • Surgery

Cite this

Chemotherapy-induced sclerosing cholangitis as a rare indication for resection : Report of a case. / Kato, Yutaro; Matsubara, Kentaro; Akiyama, Yoshinobu; Hattori, Hiroaki; Hirata, Akira; Suzuki, Fumio; Ohtaka, Hitoshi; Kato, Ayu; Sugiura, Yoshiaki; Kitajima, Masaki.

In: Surgery Today, Vol. 39, No. 10, 10.2009, p. 905-908.

Research output: Contribution to journalArticle

Kato, Y, Matsubara, K, Akiyama, Y, Hattori, H, Hirata, A, Suzuki, F, Ohtaka, H, Kato, A, Sugiura, Y & Kitajima, M 2009, 'Chemotherapy-induced sclerosing cholangitis as a rare indication for resection: Report of a case', Surgery Today, vol. 39, no. 10, pp. 905-908. https://doi.org/10.1007/s00595-008-3943-z
Kato, Yutaro ; Matsubara, Kentaro ; Akiyama, Yoshinobu ; Hattori, Hiroaki ; Hirata, Akira ; Suzuki, Fumio ; Ohtaka, Hitoshi ; Kato, Ayu ; Sugiura, Yoshiaki ; Kitajima, Masaki. / Chemotherapy-induced sclerosing cholangitis as a rare indication for resection : Report of a case. In: Surgery Today. 2009 ; Vol. 39, No. 10. pp. 905-908.
@article{ca29df16edbe4b72b6c13a4edf9a546a,
title = "Chemotherapy-induced sclerosing cholangitis as a rare indication for resection: Report of a case",
abstract = "Bile duct stricture due to chemotherapy-induced sclerosing cholangitis (CISC) is a potentially fatal complication of hepatic arterial infusion chemotherapy (HAIC). It is managed primarily with medical treatment and biliary stenting. We report a rare case of a CISC-related biliary stricture requiring resection. The patient had been receiving adjuvant HAIC for 11 months after a curative liver resection for hepatocellular carcinoma, when clinically overt cholangitis developed. Radiologic and biopsy findings suggested a CISC-related biliary stricture limited to the common hepatic duct. We discontinued HAIC and started corticosteroid treatment, which finally became ineffective. Endoscopic biliary stenting was impossible because of her severe biliary sclerosis, necessitating resection of the stricture, which was confirmed histologically to be secondary sclerosing cholangitis. The patient has shown no signs of recurrent cholangitis for 12 postoperative months since her operation. Thus, resection could be a treatment option for a CISC-related biliary stricture in selected patients.",
keywords = "Bile duct, Hepatic arterial infusion chemotherapy, Resection, Sclerosing cholangitis, Stricture",
author = "Yutaro Kato and Kentaro Matsubara and Yoshinobu Akiyama and Hiroaki Hattori and Akira Hirata and Fumio Suzuki and Hitoshi Ohtaka and Ayu Kato and Yoshiaki Sugiura and Masaki Kitajima",
year = "2009",
month = "10",
doi = "10.1007/s00595-008-3943-z",
language = "English",
volume = "39",
pages = "905--908",
journal = "Surgery Today",
issn = "0941-1291",
publisher = "Springer Japan",
number = "10",

}

TY - JOUR

T1 - Chemotherapy-induced sclerosing cholangitis as a rare indication for resection

T2 - Report of a case

AU - Kato, Yutaro

AU - Matsubara, Kentaro

AU - Akiyama, Yoshinobu

AU - Hattori, Hiroaki

AU - Hirata, Akira

AU - Suzuki, Fumio

AU - Ohtaka, Hitoshi

AU - Kato, Ayu

AU - Sugiura, Yoshiaki

AU - Kitajima, Masaki

PY - 2009/10

Y1 - 2009/10

N2 - Bile duct stricture due to chemotherapy-induced sclerosing cholangitis (CISC) is a potentially fatal complication of hepatic arterial infusion chemotherapy (HAIC). It is managed primarily with medical treatment and biliary stenting. We report a rare case of a CISC-related biliary stricture requiring resection. The patient had been receiving adjuvant HAIC for 11 months after a curative liver resection for hepatocellular carcinoma, when clinically overt cholangitis developed. Radiologic and biopsy findings suggested a CISC-related biliary stricture limited to the common hepatic duct. We discontinued HAIC and started corticosteroid treatment, which finally became ineffective. Endoscopic biliary stenting was impossible because of her severe biliary sclerosis, necessitating resection of the stricture, which was confirmed histologically to be secondary sclerosing cholangitis. The patient has shown no signs of recurrent cholangitis for 12 postoperative months since her operation. Thus, resection could be a treatment option for a CISC-related biliary stricture in selected patients.

AB - Bile duct stricture due to chemotherapy-induced sclerosing cholangitis (CISC) is a potentially fatal complication of hepatic arterial infusion chemotherapy (HAIC). It is managed primarily with medical treatment and biliary stenting. We report a rare case of a CISC-related biliary stricture requiring resection. The patient had been receiving adjuvant HAIC for 11 months after a curative liver resection for hepatocellular carcinoma, when clinically overt cholangitis developed. Radiologic and biopsy findings suggested a CISC-related biliary stricture limited to the common hepatic duct. We discontinued HAIC and started corticosteroid treatment, which finally became ineffective. Endoscopic biliary stenting was impossible because of her severe biliary sclerosis, necessitating resection of the stricture, which was confirmed histologically to be secondary sclerosing cholangitis. The patient has shown no signs of recurrent cholangitis for 12 postoperative months since her operation. Thus, resection could be a treatment option for a CISC-related biliary stricture in selected patients.

KW - Bile duct

KW - Hepatic arterial infusion chemotherapy

KW - Resection

KW - Sclerosing cholangitis

KW - Stricture

UR - http://www.scopus.com/inward/record.url?scp=70349554652&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70349554652&partnerID=8YFLogxK

U2 - 10.1007/s00595-008-3943-z

DO - 10.1007/s00595-008-3943-z

M3 - Article

C2 - 19784733

AN - SCOPUS:70349554652

VL - 39

SP - 905

EP - 908

JO - Surgery Today

JF - Surgery Today

SN - 0941-1291

IS - 10

ER -