TY - JOUR
T1 - Childhood bacterial meningitis trends in Japan from 2007 to 2008
AU - Sunakawa, Keisuke
AU - Sakai, Fuminori
AU - Hirao, Yuriko
AU - Hanaki, Hideaki
AU - Nonoyama, Masato
AU - Iwata, Satoshi
AU - Akita, Hironobu
AU - Sato, Yoshitake
PY - 2010/1
Y1 - 2010/1
N2 - We surveyed pediatrics bacterial meningitis epidemiology from January 2007 to December 2008 in Japan, with the following results: Cases numbered 287-160 male and 127 female-equivalent to 1.54-1.62 of 1,000 pediatric hospitalization per year. Children under 1-year-old accounted for the highest number of cases, which decreased with increasing age. Haemophilus influenzae was the most common cause of infection, followed by Streptococcus pneumoniae, group B streptococcus (GBS), and Escherichia coli. GBS and E. coli were major pathogens in children under 4 months of age, while H. influenzae and S. pneumoniae mainly accounted for those over 4 months of age. Susceptibility tests showed that 51% of H. influenzae isolates and 56.5% of S. pneumoniae isolates in 2008 were drug-resistant. Ampicillin combined with cephem antibiotics effective against GBS, E. coli, and Listeria, were mainly used to initially treat those under 4 months of age. In those over 4 months of age, carbapenem antibiotics are effective against PRSP and cephem antibiotics against H. influenza.
AB - We surveyed pediatrics bacterial meningitis epidemiology from January 2007 to December 2008 in Japan, with the following results: Cases numbered 287-160 male and 127 female-equivalent to 1.54-1.62 of 1,000 pediatric hospitalization per year. Children under 1-year-old accounted for the highest number of cases, which decreased with increasing age. Haemophilus influenzae was the most common cause of infection, followed by Streptococcus pneumoniae, group B streptococcus (GBS), and Escherichia coli. GBS and E. coli were major pathogens in children under 4 months of age, while H. influenzae and S. pneumoniae mainly accounted for those over 4 months of age. Susceptibility tests showed that 51% of H. influenzae isolates and 56.5% of S. pneumoniae isolates in 2008 were drug-resistant. Ampicillin combined with cephem antibiotics effective against GBS, E. coli, and Listeria, were mainly used to initially treat those under 4 months of age. In those over 4 months of age, carbapenem antibiotics are effective against PRSP and cephem antibiotics against H. influenza.
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U2 - 10.11150/kansenshogakuzasshi.84.33
DO - 10.11150/kansenshogakuzasshi.84.33
M3 - Article
C2 - 20170012
AN - SCOPUS:77949884536
SN - 0387-5911
VL - 84
SP - 33
EP - 41
JO - Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases
JF - Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases
IS - 1
ER -