A good mix: The title reaction of o-alkynylacetophenones with the Hantzsch ester in the presence of a chiral copper/phosphate catalyst proceeds in good yields with excellent enantioselectivities. The key intermediate for enantiocontrol is the ion pair of the carbonyl ylide with a chiral phosphate anion, and this process provides straight forward access to highly enantioriched chiral isochromenes.
|Number of pages||5|
|Journal||Angewandte Chemie - International Edition|
|Publication status||Published - 2013 Dec 9|
- asymmetric catalysis
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