Chiral Phosphoric Acid Catalyzed Asymmetric Synthesis of 2-Substituted 2,3-Dihydro-4-quinolones by a Protecting-Group-Free Approach

Kodai Saito; Yuka Moriya; Takahiko Akiyama

doi:10.1021/acs.orglett.5b01654

Chiral Phosphoric Acid Catalyzed Asymmetric Synthesis of 2-Substituted 2,3-Dihydro-4-quinolones by a Protecting-Group-Free Approach

Kodai Saito, Yuka Moriya, Takahiko Akiyama

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

Chiral 2-substituted 2,3-dihydro-4-quinolones were synthesized based on the chiral phosphoric acid catalyzed intramolecular aza-Michael addition reaction using N-unprotected 2-aminophenyl vinyl ketones as substrates in good yields with high enantioselectivities. (Chemical Equation Presented).

Original language	English
Pages (from-to)	3202-3205
Number of pages	4
Journal	Organic Letters
Volume	17
Issue number	13
DOIs	https://doi.org/10.1021/acs.orglett.5b01654
Publication status	Published - 2015 Jul 2
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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abstract = "Chiral 2-substituted 2,3-dihydro-4-quinolones were synthesized based on the chiral phosphoric acid catalyzed intramolecular aza-Michael addition reaction using N-unprotected 2-aminophenyl vinyl ketones as substrates in good yields with high enantioselectivities. (Chemical Equation Presented).",

author = "Kodai Saito and Yuka Moriya and Takahiko Akiyama",

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AU - Akiyama, Takahiko

PY - 2015/7/2

Y1 - 2015/7/2

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AB - Chiral 2-substituted 2,3-dihydro-4-quinolones were synthesized based on the chiral phosphoric acid catalyzed intramolecular aza-Michael addition reaction using N-unprotected 2-aminophenyl vinyl ketones as substrates in good yields with high enantioselectivities. (Chemical Equation Presented).

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Chiral Phosphoric Acid Catalyzed Asymmetric Synthesis of 2-Substituted 2,3-Dihydro-4-quinolones by a Protecting-Group-Free Approach

Abstract

ASJC Scopus subject areas

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