Chiral Phosphoric Acid Catalyzed Asymmetric Synthesis of 2-Substituted 2,3-Dihydro-4-quinolones by a Protecting-Group-Free Approach

Kodai Saito, Yuka Moriya, Takahiko Akiyama

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24 Citations (Scopus)

Abstract

Chiral 2-substituted 2,3-dihydro-4-quinolones were synthesized based on the chiral phosphoric acid catalyzed intramolecular aza-Michael addition reaction using N-unprotected 2-aminophenyl vinyl ketones as substrates in good yields with high enantioselectivities. (Chemical Equation Presented).

Original languageEnglish
Pages (from-to)3202-3205
Number of pages4
JournalOrganic Letters
Volume17
Issue number13
DOIs
Publication statusPublished - 2015 Jul 2
Externally publishedYes

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ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

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