Chiral phosphoric acid-catalyzed oxidative kinetic resolution of indolines based on transfer hydrogenation to imines

Kodai Saito, Yukihiro Shibata, Masahiro Yamanaka, Takahiko Akiyama

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

The oxidative kinetic resolution of 2-substituted indoline derivatives was achieved by hydrogen transfer to imines by means of a chiral phosphoric acid catalyst. The oxidative kinetic resolution was applicable to racemic alkyl- or aryl-substituted indolines, and the remaining indolines were obtained in good yields with excellent enantioselectivities.

Original languageEnglish
Pages (from-to)11740-11743
Number of pages4
JournalJournal of the American Chemical Society
Volume135
Issue number32
DOIs
Publication statusPublished - 2013 Aug 14
Externally publishedYes

Fingerprint

Imines
Hydrogenation
Phosphoric acid
Kinetics
Enantioselectivity
Derivatives
Hydrogen
Catalysts
phosphoric acid
indoline

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Chiral phosphoric acid-catalyzed oxidative kinetic resolution of indolines based on transfer hydrogenation to imines. / Saito, Kodai; Shibata, Yukihiro; Yamanaka, Masahiro; Akiyama, Takahiko.

In: Journal of the American Chemical Society, Vol. 135, No. 32, 14.08.2013, p. 11740-11743.

Research output: Contribution to journalArticle

Saito, Kodai ; Shibata, Yukihiro ; Yamanaka, Masahiro ; Akiyama, Takahiko. / Chiral phosphoric acid-catalyzed oxidative kinetic resolution of indolines based on transfer hydrogenation to imines. In: Journal of the American Chemical Society. 2013 ; Vol. 135, No. 32. pp. 11740-11743.
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