Cholesteryl Ester Transfer Protein, Coronary Calcium, and Intima-Media Thickness of the Carotid Artery in Middle-Age Japanese Men

Tomonori Okamura, Akira Sekikawa, Takashi Kadowaki, Aiman El-Saed, Robert D. Abbott, J. David Curb, Daniel Edmundowicz, Yasuyuki Nakamura, Kiyoshi Murata, Atsunori Kashiwagi, Kim Sutton-Tyrrell, Rhobert W. Evans, Joseph M. Zmuda, Hiroshi Maegawa, Atsushi Hozawa, Ken Ichi Mitsunami, Yoshihiko Nishio, Iva Miljkovic-Gacic, Minoru Horie, Naomi MiyamatsuYoshitaka Murakami, Lewis H. Kuller, Hirotsugu Ueshima

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Abstract

The relation between cholesteryl ester transfer protein (CETP) levels and atherosclerosis is controversial. We examined whether the serum CETP levels were associated with subclinical atherosclerosis, independent of its most common gene variant, in a sample of Japanese men. A population-based cross-sectional study of 250 Japanese men aged 40 to 49 years was conducted to assess the intima-media thickness of the carotid artery, coronary artery calcium, serum CETP levels, and the CETP D442G gene variant. Compared with the lowest CETP quartile, the multivariate adjusted odds ratio for coronary artery calcium was 0.77 (95% confidence interval 0.18 to 3.36), 0.96 (95% confidence interval 0.27 to 3.40), and 3.49 (95% confidence interval 1.05 to 11.6) with increasing CETP quartiles. The serum CETP quartiles were also positively associated with the intima-media thickness of the carotid artery (adjusted mean 602, 616, 615, and 646 μm for the lowest to top quartile, respectively). The findings remained unchanged after additional adjustment for the CETP D442G gene variant. No significant difference was found in the prevalence of coronary artery calcium or in the mean intima-media thickness of the carotid artery between participants with and without the CETP D442G gene variant.

Original languageEnglish
Pages (from-to)818-822
Number of pages5
JournalAmerican Journal of Cardiology
Volume104
Issue number6
DOIs
Publication statusPublished - 2009 Sep 15
Externally publishedYes

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ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Okamura, T., Sekikawa, A., Kadowaki, T., El-Saed, A., Abbott, R. D., Curb, J. D., Edmundowicz, D., Nakamura, Y., Murata, K., Kashiwagi, A., Sutton-Tyrrell, K., Evans, R. W., Zmuda, J. M., Maegawa, H., Hozawa, A., Mitsunami, K. I., Nishio, Y., Miljkovic-Gacic, I., Horie, M., ... Ueshima, H. (2009). Cholesteryl Ester Transfer Protein, Coronary Calcium, and Intima-Media Thickness of the Carotid Artery in Middle-Age Japanese Men. American Journal of Cardiology, 104(6), 818-822. https://doi.org/10.1016/j.amjcard.2009.05.021