Cholesteryl ester transfer protein polymorphism associated with macroangiopathy in Japanese patients with type 2 diabetes

Shu Meguro, Izumi Takei, Mitsuru Murata, Hiroshi Hirose, Naoyuki Takei, Yasutaka Mitsuyoshi, Keiko Ishii, Shuji Oguchi, Junko Shinohara, Eiko Takeshita, Kiyoaki Watanabe, Takao Saruta

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

A polymorphism in the gene for cholesteryl ester transfer protein (CETP) has been reported to be associated with serum cholesterol levels and risk for atherosclerotic vascular diseases, and to clarify the relationship between the gene polymorphism for CETP and macroangiopathy in diabetes mellitus, a cross-sectional study was performed. The subjects of the study were182 Japanese (age: 59.6±8.6 years) with type 2 diabetes and no signs of renal dysfunction, 24 of whom had macroangiopathy, and 158 of whom did not. The genotype of the subjects for the TaqIB polymorphism of CETP in intron one was analyzed by using polymerase chain reaction - restriction fragment length polymorphism. Serum CETP levels were significantly higher in the B1/B1 genotype than in the other genotypes (P<0.05). The serum CETP levels were correlated with the serum LDL cholesterol levels (P<0.01), but not with the HDL cholesterol levels. Macroangiopathy was more frequently observed in subjects with the B1/B1 genotype than in the other genotypes (odds ratio=2.953, 95% confidence interval=1.250-6.977, P=0.0136). Logistic regression analysis revealed that the CETP genotype was independently associated with macroangiopathy. The exact mechanism underlying the association remains unknown, but differences in serum CETP levels may be involved.

Original languageEnglish
Pages (from-to)151-156
Number of pages6
JournalAtherosclerosis
Volume156
Issue number1
DOIs
Publication statusPublished - 2001 May

Fingerprint

Cholesterol Ester Transfer Proteins
Type 2 Diabetes Mellitus
Genotype
Blood Proteins
Inteins
Serum
Vascular Diseases
Restriction Fragment Length Polymorphisms
LDL Cholesterol
HDL Cholesterol
Genes
Diabetes Mellitus
Cross-Sectional Studies
Logistic Models
Odds Ratio
Cholesterol
Regression Analysis
Confidence Intervals
Kidney
Polymerase Chain Reaction

Keywords

  • Atherosclerosis
  • Cholesteryl ester transfer protein
  • Polymorphism
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Cholesteryl ester transfer protein polymorphism associated with macroangiopathy in Japanese patients with type 2 diabetes. / Meguro, Shu; Takei, Izumi; Murata, Mitsuru; Hirose, Hiroshi; Takei, Naoyuki; Mitsuyoshi, Yasutaka; Ishii, Keiko; Oguchi, Shuji; Shinohara, Junko; Takeshita, Eiko; Watanabe, Kiyoaki; Saruta, Takao.

In: Atherosclerosis, Vol. 156, No. 1, 05.2001, p. 151-156.

Research output: Contribution to journalArticle

Meguro, S, Takei, I, Murata, M, Hirose, H, Takei, N, Mitsuyoshi, Y, Ishii, K, Oguchi, S, Shinohara, J, Takeshita, E, Watanabe, K & Saruta, T 2001, 'Cholesteryl ester transfer protein polymorphism associated with macroangiopathy in Japanese patients with type 2 diabetes', Atherosclerosis, vol. 156, no. 1, pp. 151-156. https://doi.org/10.1016/S0021-9150(00)00606-7
Meguro, Shu ; Takei, Izumi ; Murata, Mitsuru ; Hirose, Hiroshi ; Takei, Naoyuki ; Mitsuyoshi, Yasutaka ; Ishii, Keiko ; Oguchi, Shuji ; Shinohara, Junko ; Takeshita, Eiko ; Watanabe, Kiyoaki ; Saruta, Takao. / Cholesteryl ester transfer protein polymorphism associated with macroangiopathy in Japanese patients with type 2 diabetes. In: Atherosclerosis. 2001 ; Vol. 156, No. 1. pp. 151-156.
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