Chondromodulin I is a bone remodeling factor

Yuko Nakamichi, Chisa Shukunami, Takashi Yamada, Ken ichi Aihara, Hirotaka Kawano, Takashi Sato, Yuriko Nishizaki, Yoko Yamamoto, Masayo Shindo, Kimihiro Yoshimura, Takashi Nakamura, Naoyuki Takahashi, Hiroshi Kawaguchi, Yuji Hiraki, Shigeaki Kato

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46 Citations (Scopus)


Chondromodulin I (ChM-I) was supposed from its limited expression in cartilage and its functions in cultured chondrocytes as a major regulator in cartilage development. Here, we generated mice deficient in ChM-I by targeted disruption of the ChM-I gene. No overt abnormality was detected in endochondral bone formation during embryogenesis and cartilage development during growth stages of ChM-I-/- mice. However, a significant increase in bone mineral density with lowered bone resorption with respect to formation was unexpectedly found in adult ChM-I-/- mice. Thus, the present study established that ChM-I is a bone remodeling factor.

Original languageEnglish
Pages (from-to)636-644
Number of pages9
JournalMolecular and Cellular Biology
Issue number2
Publication statusPublished - 2003 Jan
Externally publishedYes


ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Nakamichi, Y., Shukunami, C., Yamada, T., Aihara, K. I., Kawano, H., Sato, T., Nishizaki, Y., Yamamoto, Y., Shindo, M., Yoshimura, K., Nakamura, T., Takahashi, N., Kawaguchi, H., Hiraki, Y., & Kato, S. (2003). Chondromodulin I is a bone remodeling factor. Molecular and Cellular Biology, 23(2), 636-644.