Chondromodulin-I maintains normal cardiac valves by preventing angiogensis

Daihiko Hakuno, Naritaka Kimura, Masatoyo Yoshioka, Keiichi Fukuda

Research output: Contribution to journalReview article

Abstract

We recently identified chondromodulin-I as a crucial antiangiogenic factor for maintaining cardiac valvular function. Normally, avascular cardiac valves from ApoE-/- mice and humans with valvular heart disease showed angiogenesis and increased expression of vascular endothelial cell growth factor and matrix metalloproteinases, with downregulation of chondromodulin-I. Conditioned medium from cultured valvular interstitial cells inhibited tube formation and migration of endothelial cells, and this effect was rescued by chondromodulin-I siRNA. Cardiac valves of chondromodulin-I-knockout mice showed neovascularization, lipid deposition and calcification, indicating early aortic stenosis. These findings implicated chondromodulin-I as a critical factor for maintaining normal cardiac valves by preventing angiogenesis.

Original languageEnglish
Pages (from-to)177-184
Number of pages8
JournalDrug Discovery Today: Disease Models
Volume4
Issue number4
DOIs
Publication statusPublished - 2007 Dec 1

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ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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