Chromatin Remodeling and Immediate Early Gene Activation by SLFN11 in Response to Replication Stress

Junko Murai, Hongliang Zhang, Lorinc Pongor, Sai Wen Tang, Ukhyun Jo, Fumiya Moribe, Yixiao Ma, Masaru Tomita, Yves Pommier

Research output: Contribution to journalArticlepeer-review

Abstract

Schlafen 11 (SLFN11), a promising therapeutic biomarker, binds chromatin and sensitizes cancer cells to DNA-targeting agents by blocking DNA replication. Murai et al. show that, in response to replication stress, SLFN11 selectively increases chromatin accessibility at promoters and activates a subset of genes known as the immediate early genes (IEGs).

Original languageEnglish
Pages (from-to)4137-4151.e6
JournalCell Reports
Volume30
Issue number12
DOIs
Publication statusPublished - 2020 Mar 24

Keywords

  • ATR
  • CHK1
  • DNA damage
  • FOS
  • JUN
  • cell cycle checkpoint
  • chromatin
  • native immune response
  • replication stress
  • topoisomerase inhibitor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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