Chronic enteropathy associated with SLCO2A1 gene [CEAS]-Characterisation of an enteric disorder to be considered in the differential diagnosis of Crohn's disease

CEAS Atlas Group

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Small intestinal ulcers include mucosal damage caused by drugs, particularly nonsteroidal antiinflammatory drugs [NSAIDs], infectious diseases, and idiopathic inflammatory bowel disease. Previously, a group of Japanese investigators reported an unusual and uncommon type of enteritis and referred to the condition as chronic nonspecific multiple ulcers of the small intestine [CNSU]. CNSU is characterised by chronic blood and protein loss through persistent small intestinal ulcers. Recently, four candidate mutations in the solute carrier organic anion transporter family, member 2A1 [SLCO2A1] gene, encoding a prostaglandin transporter, were identified by wholeexome sequencing in patients with CNSU. However, because the name 'CNSU' was somewhat ambiguous, the more appropriate nomenclature of 'chronic enteropathy associated with the SLCO2A1 gene' [CEAS] has been suggested. CEAS ulcers are characterised by multiple, circular or eccentric oblique, shallow lesions with discrete margins. The most frequently affected site of CEAS is the ileum, in contrast to 'cryptogenic multifocal ulcerous stenosing enteritis [CMUSE]', for which the most frequent site is the jejunum. Impaired prostaglandin utilisation is thought to cause the small intestinal mucosal damage observed in CEAS, CMUSE, and NSAID-induced enteropathy. This review article focuses on endoscopic and clinical features of genetically diagnosed CEAS, accumulated in a nationwide survey, and illustrates the observations in the format of an atlas.

Original languageEnglish
Pages (from-to)1277-1281
Number of pages5
JournalJournal of Crohn's and Colitis
Volume11
Issue number10
DOIs
Publication statusPublished - 2017 Oct 1

Fingerprint

Crohn Disease
Differential Diagnosis
Ulcer
Enteritis
Genes
Prostaglandins
Anti-Inflammatory Agents
Organic Anion Transporters
Pharmaceutical Preparations
Atlases
Jejunum
Ileum
Inflammatory Bowel Diseases
Terminology
Small Intestine
Names
Communicable Diseases
Blood Proteins
Research Personnel
Mutation

Keywords

  • Balloon-assisted enteroscopy
  • Small intestine
  • Video capsule endoscopy

ASJC Scopus subject areas

  • Gastroenterology

Cite this

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title = "Chronic enteropathy associated with SLCO2A1 gene [CEAS]-Characterisation of an enteric disorder to be considered in the differential diagnosis of Crohn's disease",
abstract = "Small intestinal ulcers include mucosal damage caused by drugs, particularly nonsteroidal antiinflammatory drugs [NSAIDs], infectious diseases, and idiopathic inflammatory bowel disease. Previously, a group of Japanese investigators reported an unusual and uncommon type of enteritis and referred to the condition as chronic nonspecific multiple ulcers of the small intestine [CNSU]. CNSU is characterised by chronic blood and protein loss through persistent small intestinal ulcers. Recently, four candidate mutations in the solute carrier organic anion transporter family, member 2A1 [SLCO2A1] gene, encoding a prostaglandin transporter, were identified by wholeexome sequencing in patients with CNSU. However, because the name 'CNSU' was somewhat ambiguous, the more appropriate nomenclature of 'chronic enteropathy associated with the SLCO2A1 gene' [CEAS] has been suggested. CEAS ulcers are characterised by multiple, circular or eccentric oblique, shallow lesions with discrete margins. The most frequently affected site of CEAS is the ileum, in contrast to 'cryptogenic multifocal ulcerous stenosing enteritis [CMUSE]', for which the most frequent site is the jejunum. Impaired prostaglandin utilisation is thought to cause the small intestinal mucosal damage observed in CEAS, CMUSE, and NSAID-induced enteropathy. This review article focuses on endoscopic and clinical features of genetically diagnosed CEAS, accumulated in a nationwide survey, and illustrates the observations in the format of an atlas.",
keywords = "Balloon-assisted enteroscopy, Small intestine, Video capsule endoscopy",
author = "{CEAS Atlas Group} and Naoki Hosoe and Naoki Ohmiy and Fumihito Hirai and Junji Umeno and Motohiro Esaki and Hirokazu Yamagami and Kei Onoder and Shigeki Bamba and Hiroyuki Imaed and Shunichi Yanai and Tadakazu Hisamatsu and Haruhiko Ogata and Takayuki Matsumoto and Shinichiro Shinzaki and Tomonori Yano and Yoshiki Okita and Toshimitsu Araki and Masayuki Saruta and Kazuo Ohtsuka and Keiji Ozeki and Yoshitaka Ueno and Koichi Kurahara and Makoto Sasaki and Tomoyuki Tsujikawa and Makoto Naganuma and Toshifumi Hibi and Takanori Kanai",
year = "2017",
month = "10",
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doi = "10.1093/ecco-jcc/jjx068",
language = "English",
volume = "11",
pages = "1277--1281",
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T1 - Chronic enteropathy associated with SLCO2A1 gene [CEAS]-Characterisation of an enteric disorder to be considered in the differential diagnosis of Crohn's disease

AU - CEAS Atlas Group

AU - Hosoe, Naoki

AU - Ohmiy, Naoki

AU - Hirai, Fumihito

AU - Umeno, Junji

AU - Esaki, Motohiro

AU - Yamagami, Hirokazu

AU - Onoder, Kei

AU - Bamba, Shigeki

AU - Imaed, Hiroyuki

AU - Yanai, Shunichi

AU - Hisamatsu, Tadakazu

AU - Ogata, Haruhiko

AU - Matsumoto, Takayuki

AU - Shinzaki, Shinichiro

AU - Yano, Tomonori

AU - Okita, Yoshiki

AU - Araki, Toshimitsu

AU - Saruta, Masayuki

AU - Ohtsuka, Kazuo

AU - Ozeki, Keiji

AU - Ueno, Yoshitaka

AU - Kurahara, Koichi

AU - Sasaki, Makoto

AU - Tsujikawa, Tomoyuki

AU - Naganuma, Makoto

AU - Hibi, Toshifumi

AU - Kanai, Takanori

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Small intestinal ulcers include mucosal damage caused by drugs, particularly nonsteroidal antiinflammatory drugs [NSAIDs], infectious diseases, and idiopathic inflammatory bowel disease. Previously, a group of Japanese investigators reported an unusual and uncommon type of enteritis and referred to the condition as chronic nonspecific multiple ulcers of the small intestine [CNSU]. CNSU is characterised by chronic blood and protein loss through persistent small intestinal ulcers. Recently, four candidate mutations in the solute carrier organic anion transporter family, member 2A1 [SLCO2A1] gene, encoding a prostaglandin transporter, were identified by wholeexome sequencing in patients with CNSU. However, because the name 'CNSU' was somewhat ambiguous, the more appropriate nomenclature of 'chronic enteropathy associated with the SLCO2A1 gene' [CEAS] has been suggested. CEAS ulcers are characterised by multiple, circular or eccentric oblique, shallow lesions with discrete margins. The most frequently affected site of CEAS is the ileum, in contrast to 'cryptogenic multifocal ulcerous stenosing enteritis [CMUSE]', for which the most frequent site is the jejunum. Impaired prostaglandin utilisation is thought to cause the small intestinal mucosal damage observed in CEAS, CMUSE, and NSAID-induced enteropathy. This review article focuses on endoscopic and clinical features of genetically diagnosed CEAS, accumulated in a nationwide survey, and illustrates the observations in the format of an atlas.

AB - Small intestinal ulcers include mucosal damage caused by drugs, particularly nonsteroidal antiinflammatory drugs [NSAIDs], infectious diseases, and idiopathic inflammatory bowel disease. Previously, a group of Japanese investigators reported an unusual and uncommon type of enteritis and referred to the condition as chronic nonspecific multiple ulcers of the small intestine [CNSU]. CNSU is characterised by chronic blood and protein loss through persistent small intestinal ulcers. Recently, four candidate mutations in the solute carrier organic anion transporter family, member 2A1 [SLCO2A1] gene, encoding a prostaglandin transporter, were identified by wholeexome sequencing in patients with CNSU. However, because the name 'CNSU' was somewhat ambiguous, the more appropriate nomenclature of 'chronic enteropathy associated with the SLCO2A1 gene' [CEAS] has been suggested. CEAS ulcers are characterised by multiple, circular or eccentric oblique, shallow lesions with discrete margins. The most frequently affected site of CEAS is the ileum, in contrast to 'cryptogenic multifocal ulcerous stenosing enteritis [CMUSE]', for which the most frequent site is the jejunum. Impaired prostaglandin utilisation is thought to cause the small intestinal mucosal damage observed in CEAS, CMUSE, and NSAID-induced enteropathy. This review article focuses on endoscopic and clinical features of genetically diagnosed CEAS, accumulated in a nationwide survey, and illustrates the observations in the format of an atlas.

KW - Balloon-assisted enteroscopy

KW - Small intestine

KW - Video capsule endoscopy

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