Chronic kidney disease is a risk factor for cardiovascular death in a community-based population in Japan - NIPPON DATA90

Koshi Nakamura, Tomonori Okamura, Takehito Hayakawa, Takashi Kadowaki, Yoshikuni Kita, Hirofumi Ohnishi, Shigeyuki Saitoh, Kiyomi Sakata, Akira Okayama, Hirotsugu Ueshima

Research output: Contribution to journalArticle

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Abstract

Background: Chronic kidney disease (CKD) has been identified as a risk factor for cardiovascular disease (CVD). Methods and Results: The risk of cardiovascular death was evaluated in a large cohort of participants selected randomly from the overall Japanese population. Participants (mean age, 52.4 years) free of previous CVD were followed up for 10 years. Glomerular filtration rate (GFR) was estimated using the abbreviated equation developed at the Cleveland Clinic laboratory for the Modification of Diet in Renal Disease study. Of the 7,316 participants, 6.7% had CKD with a GFR <60 at baseline. Even after adjustment for other risk factors, the presence of CKD conferred an increased risk of cardiovascular death with a hazard ratio of 1.20 (95% confidence interval, 0.82-1.76). Furthermore, a negative, graded correlation between GFR and risk of cardiovascular death was observed: 1.09 (0.72-1.64) for a 60≤ GFR <90, 1.15 (0.67-1.99) for a 45≤ GFR <60, 1.23 (0.49-3.09) for a 30≤ GFR <45, 5.52 (1.62-18.75) for a 15≤ GFR <30, 9.12 (2.12-39.29) for a GFR <15, as compared with normal kidney function (GFR ≥90). The proportion of excess cardiovascular death due to CKD was 1.3%. Conclusion: CKD was an independent risk factor for cardiovascular death in a community-dwelling Japanese population.

Original languageEnglish
Pages (from-to)954-959
Number of pages6
JournalCirculation Journal
Volume70
Issue number8
DOIs
Publication statusPublished - 2006
Externally publishedYes

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Glomerular Filtration Rate
Chronic Renal Insufficiency
Japan
Population
Cardiovascular Diseases
Independent Living
Diet Therapy
Kidney
Confidence Intervals

Keywords

  • Cardiovascular disease
  • Chronic kidney disease
  • Glomerular filtration rate
  • Mortality

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology

Cite this

Chronic kidney disease is a risk factor for cardiovascular death in a community-based population in Japan - NIPPON DATA90. / Nakamura, Koshi; Okamura, Tomonori; Hayakawa, Takehito; Kadowaki, Takashi; Kita, Yoshikuni; Ohnishi, Hirofumi; Saitoh, Shigeyuki; Sakata, Kiyomi; Okayama, Akira; Ueshima, Hirotsugu.

In: Circulation Journal, Vol. 70, No. 8, 2006, p. 954-959.

Research output: Contribution to journalArticle

Nakamura, K, Okamura, T, Hayakawa, T, Kadowaki, T, Kita, Y, Ohnishi, H, Saitoh, S, Sakata, K, Okayama, A & Ueshima, H 2006, 'Chronic kidney disease is a risk factor for cardiovascular death in a community-based population in Japan - NIPPON DATA90', Circulation Journal, vol. 70, no. 8, pp. 954-959. https://doi.org/10.1253/circj.70.954
Nakamura, Koshi ; Okamura, Tomonori ; Hayakawa, Takehito ; Kadowaki, Takashi ; Kita, Yoshikuni ; Ohnishi, Hirofumi ; Saitoh, Shigeyuki ; Sakata, Kiyomi ; Okayama, Akira ; Ueshima, Hirotsugu. / Chronic kidney disease is a risk factor for cardiovascular death in a community-based population in Japan - NIPPON DATA90. In: Circulation Journal. 2006 ; Vol. 70, No. 8. pp. 954-959.
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AU - Nakamura, Koshi

AU - Okamura, Tomonori

AU - Hayakawa, Takehito

AU - Kadowaki, Takashi

AU - Kita, Yoshikuni

AU - Ohnishi, Hirofumi

AU - Saitoh, Shigeyuki

AU - Sakata, Kiyomi

AU - Okayama, Akira

AU - Ueshima, Hirotsugu

PY - 2006

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N2 - Background: Chronic kidney disease (CKD) has been identified as a risk factor for cardiovascular disease (CVD). Methods and Results: The risk of cardiovascular death was evaluated in a large cohort of participants selected randomly from the overall Japanese population. Participants (mean age, 52.4 years) free of previous CVD were followed up for 10 years. Glomerular filtration rate (GFR) was estimated using the abbreviated equation developed at the Cleveland Clinic laboratory for the Modification of Diet in Renal Disease study. Of the 7,316 participants, 6.7% had CKD with a GFR <60 at baseline. Even after adjustment for other risk factors, the presence of CKD conferred an increased risk of cardiovascular death with a hazard ratio of 1.20 (95% confidence interval, 0.82-1.76). Furthermore, a negative, graded correlation between GFR and risk of cardiovascular death was observed: 1.09 (0.72-1.64) for a 60≤ GFR <90, 1.15 (0.67-1.99) for a 45≤ GFR <60, 1.23 (0.49-3.09) for a 30≤ GFR <45, 5.52 (1.62-18.75) for a 15≤ GFR <30, 9.12 (2.12-39.29) for a GFR <15, as compared with normal kidney function (GFR ≥90). The proportion of excess cardiovascular death due to CKD was 1.3%. Conclusion: CKD was an independent risk factor for cardiovascular death in a community-dwelling Japanese population.

AB - Background: Chronic kidney disease (CKD) has been identified as a risk factor for cardiovascular disease (CVD). Methods and Results: The risk of cardiovascular death was evaluated in a large cohort of participants selected randomly from the overall Japanese population. Participants (mean age, 52.4 years) free of previous CVD were followed up for 10 years. Glomerular filtration rate (GFR) was estimated using the abbreviated equation developed at the Cleveland Clinic laboratory for the Modification of Diet in Renal Disease study. Of the 7,316 participants, 6.7% had CKD with a GFR <60 at baseline. Even after adjustment for other risk factors, the presence of CKD conferred an increased risk of cardiovascular death with a hazard ratio of 1.20 (95% confidence interval, 0.82-1.76). Furthermore, a negative, graded correlation between GFR and risk of cardiovascular death was observed: 1.09 (0.72-1.64) for a 60≤ GFR <90, 1.15 (0.67-1.99) for a 45≤ GFR <60, 1.23 (0.49-3.09) for a 30≤ GFR <45, 5.52 (1.62-18.75) for a 15≤ GFR <30, 9.12 (2.12-39.29) for a GFR <15, as compared with normal kidney function (GFR ≥90). The proportion of excess cardiovascular death due to CKD was 1.3%. Conclusion: CKD was an independent risk factor for cardiovascular death in a community-dwelling Japanese population.

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KW - Chronic kidney disease

KW - Glomerular filtration rate

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