Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) after treatment for Hodgkin’s lymphoma

Kyoko Mashima, Shigeaki Suzuki, Takehiko Mori, Toshihiko Shimizu, Satoshi Yamada, Shigemichi Hirose, Shinichiro Okamoto, Norihiro Suzuki

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a rare central nervous system (CNS) disorder with distinct radiological features. However, CLIPEERS may mimic CNS lymphoma, and several cases in which CLIPPERS occurred premonitory to CNS lymphoma have been reported. We report a 31-year-old man presenting with progressive gait ataxia and the characteristic MRI features of CLIPPERS. He was diagnosed with stage II Hodgkin’s lymphoma at the age of 15, and we considered the possibility of newly emerged CNS lymphoma occurring in the immunosuppressive condition after the treatment of Hodgkin’s lymphoma. Histological findings showed no evidence of CNS lymphoma and the neurological symptoms were resolved by steroids. Although CLIPPERS developed in the reverse order in this case, CLIPPERS should be considered in different diagnosis for CNS lymphoma.

Original languageEnglish
Pages (from-to)709-712
Number of pages4
JournalInternational Journal of Hematology
Volume102
Issue number6
DOIs
Publication statusPublished - 2015 Dec 1

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Hodgkin Disease
Steroids
Lymphoma
Inflammation
Central Nervous System
Therapeutics
Gait Ataxia
Central Nervous System Diseases
Immunosuppressive Agents

Keywords

  • Brain biopsy
  • CLIPPERS
  • CNS lymphoma
  • MRI

ASJC Scopus subject areas

  • Hematology

Cite this

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) after treatment for Hodgkin’s lymphoma. / Mashima, Kyoko; Suzuki, Shigeaki; Mori, Takehiko; Shimizu, Toshihiko; Yamada, Satoshi; Hirose, Shigemichi; Okamoto, Shinichiro; Suzuki, Norihiro.

In: International Journal of Hematology, Vol. 102, No. 6, 01.12.2015, p. 709-712.

Research output: Contribution to journalArticle

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