Chronic rejection in lung allografts: Immunohistological analysis of fibrogenesis

Takeshi Hirabayashi, S. Demertzis, J. Schäfers, Ken Hoshino, Björn Nashan

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

In ongoing chronic rejection after lung transplantation, alveolar interstitial fibrosis develops. However, little is known about the mechanisms involved. In order to investigate these mechanisms, expression of extracellular matrix molecules (ECM) (undulin, decorin, tenascin, laminin, and fibronectin) and cytokines [transforming growth factor(TGF)-β1, TGF-β3, platelet-derived growth factor (PDGF), and PDGF receptor] were semiquantitatively evaluated in chronically rejected lung allografts, using standard immunohistochemical techniques. Additionally, the presence of macrophages was analysed. The present study demonstrates an increased infiltration of macrophages with a concomitant upregulation of cytokines (TGF-β1, TGF-β3, and PDGF) and an increased deposition of ECM in chronic lung rejection. These cytokines have an important role in the stimulation of fibroblasts which are a major source of ECM. Upregulated expression of ECM in the alveolar interstitial space leads to alveolar malfunction by thickening of the wall and, thus, is one of the causative factors of respiratory dys function in chronic lung graft rejection.

Original languageEnglish
JournalTransplant International
Volume9
Issue numberSUPPL. 1
Publication statusPublished - 1996

Fingerprint

Transforming Growth Factors
Extracellular Matrix
Allografts
Lung
Platelet-Derived Growth Factor
Cytokines
Macrophages
Decorin
Tenascin
Platelet-Derived Growth Factor Receptors
Lung Transplantation
Graft Rejection
Laminin
Fibronectins
Fibrosis
Up-Regulation
Fibroblasts

Keywords

  • Alveolar interstitial fibrosis
  • Chronic rejection
  • Extracellular matrix
  • PDGF
  • TGF-β

ASJC Scopus subject areas

  • Transplantation

Cite this

Hirabayashi, T., Demertzis, S., Schäfers, J., Hoshino, K., & Nashan, B. (1996). Chronic rejection in lung allografts: Immunohistological analysis of fibrogenesis. Transplant International, 9(SUPPL. 1).

Chronic rejection in lung allografts : Immunohistological analysis of fibrogenesis. / Hirabayashi, Takeshi; Demertzis, S.; Schäfers, J.; Hoshino, Ken; Nashan, Björn.

In: Transplant International, Vol. 9, No. SUPPL. 1, 1996.

Research output: Contribution to journalArticle

Hirabayashi, T, Demertzis, S, Schäfers, J, Hoshino, K & Nashan, B 1996, 'Chronic rejection in lung allografts: Immunohistological analysis of fibrogenesis', Transplant International, vol. 9, no. SUPPL. 1.
Hirabayashi T, Demertzis S, Schäfers J, Hoshino K, Nashan B. Chronic rejection in lung allografts: Immunohistological analysis of fibrogenesis. Transplant International. 1996;9(SUPPL. 1).
Hirabayashi, Takeshi ; Demertzis, S. ; Schäfers, J. ; Hoshino, Ken ; Nashan, Björn. / Chronic rejection in lung allografts : Immunohistological analysis of fibrogenesis. In: Transplant International. 1996 ; Vol. 9, No. SUPPL. 1.
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